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Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling

Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling
Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling
The reactions between inorganic sulfur and nitrogen-bearing compounds to form S–N containing species have a long history and, besides assuming importance in industrial synthetic processes, are of relevance to microbial metabolism; waste water treatment; aquatic, soil and atmospheric chemistry; and combustion processes. The recent discovery that hydrogen sulfide and nitric oxide exert often similar, sometimes mutually dependent effects in a variety of biological systems, and that the chemical interaction of these two species leads to formation of S–N compounds brought this chemistry to the attention of physiologists, biochemists and physicians. We here provide a perspective about the potential role of S–N compounds in biological signaling and briefly review their chemical properties and bioactivities in the context of the chronology of their discovery. Studies of the biological role of NO revealed why its chemistry is ideally suited for the tasks Nature has chosen for it; realising how the distinctive properties of sulfur can enrich this bioactivity does much to revive ‘die Freude am experimentellen Spiel’ of the pioneers in this field.
0300-9246
5908-5919
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Butler, Anthony R.
4e1c6bdd-2b66-44d8-9ff7-61466adf9dd3
Woollins, J. Derek
022bd545-a20d-4c91-ac16-c2a7e11a97d9
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Butler, Anthony R.
4e1c6bdd-2b66-44d8-9ff7-61466adf9dd3
Woollins, J. Derek
022bd545-a20d-4c91-ac16-c2a7e11a97d9
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd

Cortese-Krott, Miriam M., Butler, Anthony R., Woollins, J. Derek and Feelisch, Martin (2016) Inorganic sulfur–nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling. Dalton Transactions, 45 (14), 5908-5919. (doi:10.1039/c5dt05034k).

Record type: Article

Abstract

The reactions between inorganic sulfur and nitrogen-bearing compounds to form S–N containing species have a long history and, besides assuming importance in industrial synthetic processes, are of relevance to microbial metabolism; waste water treatment; aquatic, soil and atmospheric chemistry; and combustion processes. The recent discovery that hydrogen sulfide and nitric oxide exert often similar, sometimes mutually dependent effects in a variety of biological systems, and that the chemical interaction of these two species leads to formation of S–N compounds brought this chemistry to the attention of physiologists, biochemists and physicians. We here provide a perspective about the potential role of S–N compounds in biological signaling and briefly review their chemical properties and bioactivities in the context of the chronology of their discovery. Studies of the biological role of NO revealed why its chemistry is ideally suited for the tasks Nature has chosen for it; realising how the distinctive properties of sulfur can enrich this bioactivity does much to revive ‘die Freude am experimentellen Spiel’ of the pioneers in this field.

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More information

Accepted/In Press date: 12 February 2016
e-pub ahead of print date: 15 February 2016
Published date: 14 April 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 390054
URI: https://eprints.soton.ac.uk/id/eprint/390054
ISSN: 0300-9246
PURE UUID: 50633762-a987-48ce-a74f-7373fb40a7c7
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 17 Mar 2016 14:36
Last modified: 03 Dec 2019 01:39

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