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Innate and adaptive genetic pathways in HCV infection

Innate and adaptive genetic pathways in HCV infection
Innate and adaptive genetic pathways in HCV infection
Infection with hepatitis C virus (HCV) leads to a wide spectrum of clinical manifestations. This heterogeneity is underpinned by the host immune response and the genetic factors that govern it. Polymorphisms affecting both the innate and adaptive immunity determine the outcome of exposure. However the innate immune system appears to play a greater role in determining treatment-associated responses. Overall the effects of IFNL3/4 appear dominant over other polymorphic genes. Understanding how host genetics determines the disease phenotype has not been as intensively studied. This review summarizes our current understanding of innate and adaptive immunogenetic factors in the outcome of HCV infection. It focuses on how they relate to resolution and the progression of HCV-related liver disease, in the context of current and future treatment regimes.
0001-2815
231-240
Buchanan, R.
a092c890-492a-478f-8d13-0453d482a700
Hydes, T.
d842d1ec-c64a-4934-a5a2-7316fea65767
Khakoo, S.I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Buchanan, R.
a092c890-492a-478f-8d13-0453d482a700
Hydes, T.
d842d1ec-c64a-4934-a5a2-7316fea65767
Khakoo, S.I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Buchanan, R., Hydes, T. and Khakoo, S.I. (2015) Innate and adaptive genetic pathways in HCV infection. Tissue Antigens, 85 (4), 231-240. (doi:10.1111/tan.12540). (PMID:25708172)

Record type: Article

Abstract

Infection with hepatitis C virus (HCV) leads to a wide spectrum of clinical manifestations. This heterogeneity is underpinned by the host immune response and the genetic factors that govern it. Polymorphisms affecting both the innate and adaptive immunity determine the outcome of exposure. However the innate immune system appears to play a greater role in determining treatment-associated responses. Overall the effects of IFNL3/4 appear dominant over other polymorphic genes. Understanding how host genetics determines the disease phenotype has not been as intensively studied. This review summarizes our current understanding of innate and adaptive immunogenetic factors in the outcome of HCV infection. It focuses on how they relate to resolution and the progression of HCV-related liver disease, in the context of current and future treatment regimes.

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Published date: April 2015
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 390069
URI: https://eprints.soton.ac.uk/id/eprint/390069
ISSN: 0001-2815
PURE UUID: 23431b2e-f675-4f5c-adb5-2643695c926e

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Date deposited: 17 Mar 2016 16:28
Last modified: 17 Jul 2017 19:30

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Contributors

Author: R. Buchanan
Author: T. Hydes
Author: S.I. Khakoo

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