Influence of immunoglobulin isotype on therapeutic antibody function
Influence of immunoglobulin isotype on therapeutic antibody function
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirements. Here we summarize how isotype dictates mAb activity and discuss ways in which this information can be used for the development of enhanced therapeutics.
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Beers, S.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Glennie, M.
9f6f0eff-4560-48c2-80cd-0ec116110ded
White, A.
b8c81272-e959-4acb-bbfe-1adc8a6c43f0
3 March 2016
Beers, S.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Glennie, M.
9f6f0eff-4560-48c2-80cd-0ec116110ded
White, A.
b8c81272-e959-4acb-bbfe-1adc8a6c43f0
Abstract
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirements. Here we summarize how isotype dictates mAb activity and discuss ways in which this information can be used for the development of enhanced therapeutics.
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Accepted/In Press date: 9 January 2016
e-pub ahead of print date: 13 January 2016
Published date: 3 March 2016
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 390367
URI: http://eprints.soton.ac.uk/id/eprint/390367
ISSN: 0006-4971
PURE UUID: 1f1ac761-f8e5-4c01-a5d4-806f74312ba3
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Date deposited: 24 Mar 2016 16:22
Last modified: 15 Mar 2024 03:08
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Author:
A. White
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