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Influence of immunoglobulin isotype on therapeutic antibody function

Influence of immunoglobulin isotype on therapeutic antibody function
Influence of immunoglobulin isotype on therapeutic antibody function
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirements. Here we summarize how isotype dictates mAb activity and discuss ways in which this information can be used for the development of enhanced therapeutics.
0006-4971
1-6
Beers, S.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Glennie, M.
9f6f0eff-4560-48c2-80cd-0ec116110ded
White, A.
b8c81272-e959-4acb-bbfe-1adc8a6c43f0
Beers, S.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Glennie, M.
9f6f0eff-4560-48c2-80cd-0ec116110ded
White, A.
b8c81272-e959-4acb-bbfe-1adc8a6c43f0

Beers, S., Glennie, M. and White, A. (2016) Influence of immunoglobulin isotype on therapeutic antibody function. Blood, 127 (9), 1-6. (doi:10.1182/blood-2015-09-625343). (PMID:26764357)

Record type: Article

Abstract

Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that work through different mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirements. Here we summarize how isotype dictates mAb activity and discuss ways in which this information can be used for the development of enhanced therapeutics.

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More information

Accepted/In Press date: 9 January 2016
e-pub ahead of print date: 13 January 2016
Published date: 3 March 2016
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 390367
URI: http://eprints.soton.ac.uk/id/eprint/390367
DOI: doi:10.1182/blood-2015-09-625343
ISSN: 0006-4971
PURE UUID: 1f1ac761-f8e5-4c01-a5d4-806f74312ba3
ORCID for S. Beers: ORCID iD orcid.org/0000-0002-3765-3342

Catalogue record

Date deposited: 24 Mar 2016 16:22
Last modified: 15 Mar 2024 03:08

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Author: S. Beers ORCID iD
Author: M. Glennie
Author: A. White

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