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Complement pathway biomarkers and age-related macular degeneration

Complement pathway biomarkers and age-related macular degeneration
Complement pathway biomarkers and age-related macular degeneration
In the age-related macular degeneration (AMD) ‘inflammation model’, local inflammation plus complement activation contributes to the pathogenesis and progression of the disease. Multiple genetic associations have now been established correlating the risk of development or progression of AMD. Stratifying patients by their AMD genetic profile may facilitate future AMD therapeutic trials resulting in meaningful clinical trial end points with smaller sample sizes and study duration.
0950-222X
1-14
Gementzi, M.
bb9b1716-b4bc-4ae5-ae98-3da25bb2a35c
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Gementzi, M.
bb9b1716-b4bc-4ae5-ae98-3da25bb2a35c
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Gementzi, M. and Lotery, A.J. (2016) Complement pathway biomarkers and age-related macular degeneration. Eye, 30, 1-14. (doi:10.1038/eye.2015.203). (PMID:26493033)

Record type: Article

Abstract

In the age-related macular degeneration (AMD) ‘inflammation model’, local inflammation plus complement activation contributes to the pathogenesis and progression of the disease. Multiple genetic associations have now been established correlating the risk of development or progression of AMD. Stratifying patients by their AMD genetic profile may facilitate future AMD therapeutic trials resulting in meaningful clinical trial end points with smaller sample sizes and study duration.

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More information

Accepted/In Press date: 3 September 2015
e-pub ahead of print date: 23 October 2015
Published date: 30 January 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 390401
URI: http://eprints.soton.ac.uk/id/eprint/390401
ISSN: 0950-222X
PURE UUID: 6d1395b4-d91b-4504-b7a4-17167fce1fd6
ORCID for A.J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 01 Apr 2016 10:22
Last modified: 17 Dec 2019 01:49

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Contributors

Author: M. Gementzi
Author: A.J. Lotery ORCID iD

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