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Age-related macular degeneration: a disease of systemic or local complement dysregulation?

Age-related macular degeneration: a disease of systemic or local complement dysregulation?
Age-related macular degeneration: a disease of systemic or local complement dysregulation?
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver of disease. This has important implications for designing novel complement-based AMD therapies. We present a summary of the current literature and suggest that intraocular rather than systemic modulation of complement may prove more effective.
1179-9161
1234-1257
Warwick, Alasdair
efe63330-ed24-4dfe-8c88-c3f6dbf828ed
Khandhadia, Samir
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Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Warwick, Alasdair
efe63330-ed24-4dfe-8c88-c3f6dbf828ed
Khandhadia, Samir
a84355f9-8dd3-4377-864f-27fa059ad847
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Warwick, Alasdair, Khandhadia, Samir, Ennis, Sarah and Lotery, Andrew (2014) Age-related macular degeneration: a disease of systemic or local complement dysregulation? Indian Journal of Clinical Medicine, 3 (4), 1234-1257. (doi:10.3390/jcm3041234). (PMID:26237601)

Record type: Article

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver of disease. This has important implications for designing novel complement-based AMD therapies. We present a summary of the current literature and suggest that intraocular rather than systemic modulation of complement may prove more effective.

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Accepted/In Press date: 22 October 2014
Published date: 3 November 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 390431
URI: http://eprints.soton.ac.uk/id/eprint/390431
ISSN: 1179-9161
PURE UUID: c7a70569-79be-4e8d-8b82-410ee273e62e
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 01 Apr 2016 15:17
Last modified: 16 Jul 2020 00:28

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Contributors

Author: Alasdair Warwick
Author: Samir Khandhadia
Author: Sarah Ennis ORCID iD
Author: Andrew Lotery ORCID iD

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