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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.

This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.

Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12?months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.

Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach.
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Chung, K.F.
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on behalf of the U-BIOPRED Study Group, None
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Shaw, D.E.
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Fleming, L.J.
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Roberts, G.
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Corfield, J.
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Pandis, I.
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Bel, E.H.
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Chung, K.F.
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on behalf of the U-BIOPRED Study Group, None
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Shaw, D.E., Sousa, A.R., Fowler, S.J., Fleming, L.J., Roberts, G., Corfield, J., Pandis, I., Bansal, A.T., Bel, E.H., Auffray, C., Compton, C.H., Bisgaard, H., Bucchioni, E., Caruso, M., Chanez, P., Dahlen, B., Dahlen, S.E., Dyson, K., Frey, U., Geiser, T., Gerhardsson de verdier, M., Gibeon, D., Guo, Y.K., Hashimoto, S., Hedlin, G., Jeyasingham, E., Hekking, P.P., Higenbottam, T., Horvath, I., Knox, A.J., Krug, N., Erpenbeck, V.J., Larsson, L.X., Lazarinis, N., Matthews, J.G., Middelveld, R., Montuschi, P., Musial, J., Myles, D., Pahus, L., Sandstrom, T., Seibold, W., Singer, F., Strandberg, K., Vestbo, J., Vissing, N., Von Garnier, C., Adcock, I.M., Wagers, S., Rowe, A., Howarth, P., Wagener, A.H., Djukanovic, R., Sterk, P.J., Chung, K.F. and on behalf of the U-BIOPRED Study Group, None (2015) Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46 (5), 1308-1321. (doi:10.1183/13993003.00779-2015). (PMID:26357963)

Record type: Article

Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.

This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.

Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12?months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.

Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach.

Full text not available from this repository.

More information

Accepted/In Press date: 3 July 2015
Published date: 1 November 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 390628
URI: https://eprints.soton.ac.uk/id/eprint/390628
ISSN: 0903-1936
PURE UUID: a4bd8b4b-2194-4c7b-b7e1-98f925a8597b
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 05 Apr 2016 14:47
Last modified: 19 Jul 2019 01:23

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Contributors

Author: D.E. Shaw
Author: A.R. Sousa
Author: S.J. Fowler
Author: L.J. Fleming
Author: G. Roberts
Author: J. Corfield
Author: I. Pandis
Author: A.T. Bansal
Author: E.H. Bel
Author: C. Auffray
Author: C.H. Compton
Author: H. Bisgaard
Author: E. Bucchioni
Author: M. Caruso
Author: P. Chanez
Author: B. Dahlen
Author: S.E. Dahlen
Author: K. Dyson
Author: U. Frey
Author: T. Geiser
Author: M. Gerhardsson de verdier
Author: D. Gibeon
Author: Y.K. Guo
Author: S. Hashimoto
Author: G. Hedlin
Author: E. Jeyasingham
Author: P.P. Hekking
Author: T. Higenbottam
Author: I. Horvath
Author: A.J. Knox
Author: N. Krug
Author: V.J. Erpenbeck
Author: L.X. Larsson
Author: N. Lazarinis
Author: J.G. Matthews
Author: R. Middelveld
Author: P. Montuschi
Author: J. Musial
Author: D. Myles
Author: L. Pahus
Author: T. Sandstrom
Author: W. Seibold
Author: F. Singer
Author: K. Strandberg
Author: J. Vestbo
Author: N. Vissing
Author: C. Von Garnier
Author: I.M. Adcock
Author: S. Wagers
Author: A. Rowe
Author: P. Howarth
Author: A.H. Wagener
Author: R. Djukanovic ORCID iD
Author: P.J. Sterk
Author: K.F. Chung
Author: None on behalf of the U-BIOPRED Study Group

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