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Local mechanical properties of human ascending thoracic aneurysms

Local mechanical properties of human ascending thoracic aneurysms
Local mechanical properties of human ascending thoracic aneurysms
Ascending thoracic aortic aneurysms (ATAAs) are focal, asymmetric dilatations of the aortic wall which are prone to rupture. To identify potential rupture locations in advance, it is necessary to consider the inhomogeneity of the ATAA at the millimeter scale. Towards this end, we have developed a combined experimental and computational approach using bulge inflation tests, digital image correlation (DIC), and an inverse membrane approach to characterize the pointwise stress, strain, and hyperelastic properties of the ATAA. Using this approach, the pointwise hyperelastic material properties were identified on 10 human ATAA samples collected from patients undergoing elective surgery to replace their ATAAs with a graft. Our method was able to capture the varying levels of heterogeneity in the ATAA from regional to local. It was shown for the first time that the material properties in the ATAA are unmistakably heterogeneous at length scales between 1 mm and 1 cm, which are length scales where vascular tissue is typically treated as homogeneous. The distributions of the material properties for each patient were also examined to study the inter- and intra-patient variability. Large inter-subject variability was observed in the elastic properties.
1751-6161
1-27
Davis, Frances M.
20f89066-bbac-42dc-908d-d89a747dc399
Lou, Yaunming
2cc51241-5994-427c-a732-00a301aa4ae3
Avril, Stephane
2a04eeed-db32-41eb-90fe-c21674b4496f
Duprey, Ambroise
ec5b5eac-34f2-4197-8be5-eaaa5575e1ff
Lu, Jia
08c1272f-b20c-4154-84f8-63b9c34ecb7f
Davis, Frances M.
20f89066-bbac-42dc-908d-d89a747dc399
Lou, Yaunming
2cc51241-5994-427c-a732-00a301aa4ae3
Avril, Stephane
2a04eeed-db32-41eb-90fe-c21674b4496f
Duprey, Ambroise
ec5b5eac-34f2-4197-8be5-eaaa5575e1ff
Lu, Jia
08c1272f-b20c-4154-84f8-63b9c34ecb7f

Davis, Frances M., Lou, Yaunming and Avril, Stephane et al. (2016) Local mechanical properties of human ascending thoracic aneurysms. Journal of the Mechanical Behavior of Biomedical Materials, 1-27. (doi:10.1016/j.jmbbm.2016.03.025).

Record type: Article

Abstract

Ascending thoracic aortic aneurysms (ATAAs) are focal, asymmetric dilatations of the aortic wall which are prone to rupture. To identify potential rupture locations in advance, it is necessary to consider the inhomogeneity of the ATAA at the millimeter scale. Towards this end, we have developed a combined experimental and computational approach using bulge inflation tests, digital image correlation (DIC), and an inverse membrane approach to characterize the pointwise stress, strain, and hyperelastic properties of the ATAA. Using this approach, the pointwise hyperelastic material properties were identified on 10 human ATAA samples collected from patients undergoing elective surgery to replace their ATAAs with a graft. Our method was able to capture the varying levels of heterogeneity in the ATAA from regional to local. It was shown for the first time that the material properties in the ATAA are unmistakably heterogeneous at length scales between 1 mm and 1 cm, which are length scales where vascular tissue is typically treated as homogeneous. The distributions of the material properties for each patient were also examined to study the inter- and intra-patient variability. Large inter-subject variability was observed in the elastic properties.

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Accepted/In Press date: 9 March 2016
e-pub ahead of print date: 1 April 2016
Organisations: Engineering Science Unit

Identifiers

Local EPrints ID: 391004
URI: http://eprints.soton.ac.uk/id/eprint/391004
ISSN: 1751-6161
PURE UUID: 2a2046b6-c5f4-4a4c-bded-bc21e62ffd78

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Date deposited: 07 Apr 2016 14:36
Last modified: 17 Dec 2019 06:52

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