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Intramolecular guanidine epoxide ring opening reactions

Intramolecular guanidine epoxide ring opening reactions
Intramolecular guanidine epoxide ring opening reactions
The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported. A preliminary investigation of the glycosidase inhibitory activity of these substances is also discussed.
guanidines, epoxides, iodocyclisations, ?-galactosidase inhibition
0040-4039
3075-3080
Dennis, Mark
aeb7123e-786d-4ae2-bc21-72eddd61697b
Hall, Louise M.
d6af71b4-196f-4055-98a2-142798687f48
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Thornhill, Andrew J.
0d829833-e582-4a27-be68-f03af3a70e5d
Nash, Robert
a4188e5e-0a41-4cfb-888a-6dbe2255e615
Winters, Ana L.
d9d7dbb2-269f-4540-ae9c-c33f006ec988
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Horton, Peter
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Dennis, Mark
aeb7123e-786d-4ae2-bc21-72eddd61697b
Hall, Louise M.
d6af71b4-196f-4055-98a2-142798687f48
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Thornhill, Andrew J.
0d829833-e582-4a27-be68-f03af3a70e5d
Nash, Robert
a4188e5e-0a41-4cfb-888a-6dbe2255e615
Winters, Ana L.
d9d7dbb2-269f-4540-ae9c-c33f006ec988
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Light, Mark E.
cf57314e-6856-491b-a8d2-2dffc452e161
Horton, Peter
154c8930-bfc3-495b-ad4a-8a278d5da3a5

Dennis, Mark, Hall, Louise M., Murphy, Patrick J., Thornhill, Andrew J., Nash, Robert, Winters, Ana L., Hursthouse, Michael B., Light, Mark E. and Horton, Peter (2003) Intramolecular guanidine epoxide ring opening reactions. Tetrahedron Letters, 44 (15), 3075-3080. (doi:10.1016/S0040-4039(03)00519-7).

Record type: Article

Abstract

The synthesis of a range of cyclic guanidines via intramolecular ring opening of epoxides or iodocyclisation is reported. A preliminary investigation of the glycosidase inhibitory activity of these substances is also discussed.

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More information

Published date: 2003
Keywords: guanidines, epoxides, iodocyclisations, ?-galactosidase inhibition
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Identifiers

Local EPrints ID: 39108
URI: http://eprints.soton.ac.uk/id/eprint/39108
DOI: doi:10.1016/S0040-4039(03)00519-7
ISSN: 0040-4039
PURE UUID: 6b14aa28-41ce-4d05-b784-b0e6a53de324
ORCID for Mark E. Light: ORCID iD orcid.org/0000-0002-0585-0843
ORCID for Peter Horton: ORCID iD orcid.org/0000-0001-8886-2016

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Date deposited: 21 Jun 2006
Last modified: 16 Mar 2024 03:12

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Contributors

Author: Mark Dennis
Author: Louise M. Hall
Author: Patrick J. Murphy
Author: Andrew J. Thornhill
Author: Robert Nash
Author: Ana L. Winters
Author: Michael B. Hursthouse
Author: Mark E. Light ORCID iD
Author: Peter Horton ORCID iD

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