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Treatable traits: toward precision medicine of chronic airway diseases

Treatable traits: toward precision medicine of chronic airway diseases
Treatable traits: toward precision medicine of chronic airway diseases
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations”. In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.
0903-1936
410-419
Agusti, Alvar
e916da0b-126c-45bf-8ebe-af737fd32344
Bel, Elisabeth
2129da95-9ea8-47db-985a-aef7348e3484
Thomas, Mike
997c78e0-3849-4ce8-b1bc-86ebbdee3953
Vogelmeier, Claus
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Brusselle, Guy
7b8ee2aa-06d6-437c-8591-b09be09fed7b
Holgate, Stephen
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Humbert, Marc
4810a9ae-540b-4b74-a72e-df68dbea47d3
Jones, Paul
b51472fd-cbaa-4297-97ee-fd0e47ea46e4
Gibson, Peter G.
b97e6518-ae09-4080-b76a-e6025647a79f
Vestbo, Jorgen
3f725045-04d7-4c94-8701-dc62e55cc321
Beasley, Richard
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Pavord, Ian D.
ee414b70-d199-4271-be4f-408da5bcad8f
Agusti, Alvar
e916da0b-126c-45bf-8ebe-af737fd32344
Bel, Elisabeth
2129da95-9ea8-47db-985a-aef7348e3484
Thomas, Mike
997c78e0-3849-4ce8-b1bc-86ebbdee3953
Vogelmeier, Claus
6b0f601c-d255-45a6-8b37-310dad186c28
Brusselle, Guy
7b8ee2aa-06d6-437c-8591-b09be09fed7b
Holgate, Stephen
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Humbert, Marc
4810a9ae-540b-4b74-a72e-df68dbea47d3
Jones, Paul
b51472fd-cbaa-4297-97ee-fd0e47ea46e4
Gibson, Peter G.
b97e6518-ae09-4080-b76a-e6025647a79f
Vestbo, Jorgen
3f725045-04d7-4c94-8701-dc62e55cc321
Beasley, Richard
8443c9a4-f81e-4d91-924f-5b2c817c5b61
Pavord, Ian D.
ee414b70-d199-4271-be4f-408da5bcad8f

Agusti, Alvar, Bel, Elisabeth, Thomas, Mike, Vogelmeier, Claus, Brusselle, Guy, Holgate, Stephen, Humbert, Marc, Jones, Paul, Gibson, Peter G., Vestbo, Jorgen, Beasley, Richard and Pavord, Ian D. (2016) Treatable traits: toward precision medicine of chronic airway diseases. European Respiratory Journal, 47 (2), 410-419. (doi:10.1183/13993003.01359-2015). (PMID:26828055)

Record type: Article

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations”. In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.

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Accepted/In Press date: 27 October 2015
Published date: February 2016
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 391349
URI: https://eprints.soton.ac.uk/id/eprint/391349
ISSN: 0903-1936
PURE UUID: 23ae6b33-ab38-48b4-bfd1-7216048c98a1

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Date deposited: 12 Apr 2016 08:41
Last modified: 14 Oct 2019 18:40

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Contributors

Author: Alvar Agusti
Author: Elisabeth Bel
Author: Mike Thomas
Author: Claus Vogelmeier
Author: Guy Brusselle
Author: Stephen Holgate
Author: Marc Humbert
Author: Paul Jones
Author: Peter G. Gibson
Author: Jorgen Vestbo
Author: Richard Beasley
Author: Ian D. Pavord

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