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Exploring association between gastrointestinal heat retention syndrome and recurrent respiratory tract infections in children: a prospective cohort study

Exploring association between gastrointestinal heat retention syndrome and recurrent respiratory tract infections in children: a prospective cohort study
Exploring association between gastrointestinal heat retention syndrome and recurrent respiratory tract infections in children: a prospective cohort study
Background: Recurrent respiratory tract infections (RRTIs) have a negative impact on both children’s health and family wellbeing. Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Medicine (TCM). Our clinical observations suggest that children with gastrointestinal heat retention syndrome (GHRS) may have a greater risk of catching respiratory tract infections (RTIs). GHRS is a new predisposing factor for RRTI and it is dietary related. This study is aimed to explore association between GHRS and RRTI.

Methods: A prospective cohort study has been conducted in Beijing, China; children aged 1–18 were enrolled. TCM symptoms, demographic and physiological characteristics were recorded by using semi-structured questionnaire. GHRS was considered as a predisposing factor. Children were followed up for next 12 months. We contacted with their parents using a face-to-face questionnaire survey, via email or phone every 3 months. Episodes of RTIs were recorded in detail.

Results: Three hundred thirty four children were enrolled and 307 (91.92 %) followed up for 12 months. The incidence of RTI was 4.32 episodes per child-year (95 % CI 4.03–4.61). 69 (43.13 %) children in the group with GHRS suffered from RRTI; there were 48 (32.65 %) children in group without GHRS. The risk ratio (RR) value of RRTI occurrence was 1.32 (95 % CI 0.91–1.91, P?=?0.139), and the attributable risk percent (AR%) was 24.28 %. Dry stool and irritability were positively correlated with RTI episodes, age and BMI were negatively correlated with RTI episodes in a linear regression model. Dry stool (OR?=?1.510) was positively correlated with RRTI occurrence, age (OR?=?0.889) and BMI (OR?=?0.858) were negatively correlated with RRTI occurrence in our logistic regression model.

Conclusions: GHRS is associated with RRTI in this cohort. Dry stool was positively associated with RRTI, and BMI was negatively associated with RRTI. Studies with larger sample size and longer follow up are needed to further evaluate this association. Relieving GHRS should be considered when TCM practitioners treat RRTI children, and this may protect children from suffering RTIs.

Trial registration: Chinese Clinical Trial Registry Number: ChiCTR-CCH-13003756
gastrointestinal heat retention syndrome, recurrent respiratory tract infection, children, prospective cohort study
1472-6882
1-8
Dong, Fei
3ca05802-6de0-4c46-b735-bd44786ba008
Yu, He
79ec5223-2fd9-4013-b426-b36b81ef9d45
Ma, Jiaju
ee249938-2ba4-4a37-9d98-b1d8c850e8c9
Wu, Liqun
b64fa205-e74e-4cfb-8ee3-a24ea716c970
Liu, Tiegang
dcbf43df-26f3-4bab-857e-cadec1980201
Guokai, Lv
90bd9afd-dc3d-4dfe-95ff-ba155005f1b7
Zhen, Jianhua
f23896d7-19d9-47f2-b7f0-3a828b8b023d
Li, Xiaofei
5a4b5a46-9b0d-450b-a073-13894d07a3cd
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Gu, Xiaohong
5f7266b5-987b-442a-a4c9-61ff3f4c1580
Dong, Fei
3ca05802-6de0-4c46-b735-bd44786ba008
Yu, He
79ec5223-2fd9-4013-b426-b36b81ef9d45
Ma, Jiaju
ee249938-2ba4-4a37-9d98-b1d8c850e8c9
Wu, Liqun
b64fa205-e74e-4cfb-8ee3-a24ea716c970
Liu, Tiegang
dcbf43df-26f3-4bab-857e-cadec1980201
Guokai, Lv
90bd9afd-dc3d-4dfe-95ff-ba155005f1b7
Zhen, Jianhua
f23896d7-19d9-47f2-b7f0-3a828b8b023d
Li, Xiaofei
5a4b5a46-9b0d-450b-a073-13894d07a3cd
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Gu, Xiaohong
5f7266b5-987b-442a-a4c9-61ff3f4c1580

Dong, Fei, Yu, He, Ma, Jiaju, Wu, Liqun, Liu, Tiegang, Guokai, Lv, Zhen, Jianhua, Li, Xiaofei, Lewith, George and Gu, Xiaohong (2016) Exploring association between gastrointestinal heat retention syndrome and recurrent respiratory tract infections in children: a prospective cohort study. BMC Complementary and Alternative Medicine, 16 (82), 1-8. (doi:10.1186/s12906-016-1062-8). (PMID:26921252)

Record type: Article

Abstract

Background: Recurrent respiratory tract infections (RRTIs) have a negative impact on both children’s health and family wellbeing. Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Medicine (TCM). Our clinical observations suggest that children with gastrointestinal heat retention syndrome (GHRS) may have a greater risk of catching respiratory tract infections (RTIs). GHRS is a new predisposing factor for RRTI and it is dietary related. This study is aimed to explore association between GHRS and RRTI.

Methods: A prospective cohort study has been conducted in Beijing, China; children aged 1–18 were enrolled. TCM symptoms, demographic and physiological characteristics were recorded by using semi-structured questionnaire. GHRS was considered as a predisposing factor. Children were followed up for next 12 months. We contacted with their parents using a face-to-face questionnaire survey, via email or phone every 3 months. Episodes of RTIs were recorded in detail.

Results: Three hundred thirty four children were enrolled and 307 (91.92 %) followed up for 12 months. The incidence of RTI was 4.32 episodes per child-year (95 % CI 4.03–4.61). 69 (43.13 %) children in the group with GHRS suffered from RRTI; there were 48 (32.65 %) children in group without GHRS. The risk ratio (RR) value of RRTI occurrence was 1.32 (95 % CI 0.91–1.91, P?=?0.139), and the attributable risk percent (AR%) was 24.28 %. Dry stool and irritability were positively correlated with RTI episodes, age and BMI were negatively correlated with RTI episodes in a linear regression model. Dry stool (OR?=?1.510) was positively correlated with RRTI occurrence, age (OR?=?0.889) and BMI (OR?=?0.858) were negatively correlated with RRTI occurrence in our logistic regression model.

Conclusions: GHRS is associated with RRTI in this cohort. Dry stool was positively associated with RRTI, and BMI was negatively associated with RRTI. Studies with larger sample size and longer follow up are needed to further evaluate this association. Relieving GHRS should be considered when TCM practitioners treat RRTI children, and this may protect children from suffering RTIs.

Trial registration: Chinese Clinical Trial Registry Number: ChiCTR-CCH-13003756

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Accepted/In Press date: 19 February 2016
e-pub ahead of print date: 27 February 2016
Published date: 27 February 2016
Keywords: gastrointestinal heat retention syndrome, recurrent respiratory tract infection, children, prospective cohort study
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 391373
URI: https://eprints.soton.ac.uk/id/eprint/391373
ISSN: 1472-6882
PURE UUID: dca8a9bf-70ae-4c71-adf5-39d9dea80a5f

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Date deposited: 12 Apr 2016 09:08
Last modified: 19 Jul 2019 20:10

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