Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation
Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation
Via epigenome-scaled analyses using recursive RF followed by log-linear models, we identified 88 CpGs associated with eczema in F1, of which 41 were replicated in F2. Several identified CpGs are located within genes in biological pathways relating to skin barrier integrity, which is central to the pathogenesis of eczema. Novel genes associated with eczema risk were identified (e.g., the PROZ and NEU1 genes).
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Quraishi, B.M.
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Zhang, H.
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Everson, T.M.
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Ray, M.
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Lockett, G.
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Holloway, J.W.
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Tetali, S.R.
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Arshad, S.H.
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Kaushal, A.
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Rezwan, F.
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Karmaus, W.
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21 July 2015
Quraishi, B.M.
512063bd-89eb-4514-8c2f-2633c1447fb7
Zhang, H.
49b0dd51-9e3e-4c73-ac6f-af1bd3a9bcd0
Everson, T.M.
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Ray, M.
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Lockett, G.
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Holloway, J.W.
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Tetali, S.R.
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Arshad, S.H.
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Kaushal, A.
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Rezwan, F.
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Karmaus, W.
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Quraishi, B.M., Zhang, H., Everson, T.M., Ray, M., Lockett, G., Holloway, J.W., Tetali, S.R., Arshad, S.H., Kaushal, A., Rezwan, F. and Karmaus, W.
(2015)
Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation.
Clinical Epigenetics, 7 (68), .
(doi:10.1186/s13148-015-0108-y).
(PMID:26199674)
Abstract
Via epigenome-scaled analyses using recursive RF followed by log-linear models, we identified 88 CpGs associated with eczema in F1, of which 41 were replicated in F2. Several identified CpGs are located within genes in biological pathways relating to skin barrier integrity, which is central to the pathogenesis of eczema. Novel genes associated with eczema risk were identified (e.g., the PROZ and NEU1 genes).
Text
art%3A10.1186%2Fs13148-015-0108-y.pdf
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Accepted/In Press date: 2 January 2015
Published date: 21 July 2015
Organisations:
Human Development & Health, Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 392003
URI: http://eprints.soton.ac.uk/id/eprint/392003
ISSN: 1868-7075
PURE UUID: 68ad4e38-16b5-46ad-b5a3-bc96e2f1980d
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Date deposited: 13 Apr 2016 14:20
Last modified: 15 Mar 2024 03:45
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Contributors
Author:
B.M. Quraishi
Author:
H. Zhang
Author:
T.M. Everson
Author:
M. Ray
Author:
G. Lockett
Author:
S.R. Tetali
Author:
A. Kaushal
Author:
F. Rezwan
Author:
W. Karmaus
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