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Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation

Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation
Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation
Via epigenome-scaled analyses using recursive RF followed by log-linear models, we identified 88 CpGs associated with eczema in F1, of which 41 were replicated in F2. Several identified CpGs are located within genes in biological pathways relating to skin barrier integrity, which is central to the pathogenesis of eczema. Novel genes associated with eczema risk were identified (e.g., the PROZ and NEU1 genes).
1868-7075
1-11
Quraishi, B.M.
512063bd-89eb-4514-8c2f-2633c1447fb7
Zhang, H.
49b0dd51-9e3e-4c73-ac6f-af1bd3a9bcd0
Everson, T.M.
cd2903f2-f8d9-4805-9d5c-0b33736130a2
Ray, M.
7f2001c1-5d01-4a81-b238-0a70f6e176e8
Lockett, G.
4d92a28c-f54c-431b-81f6-e82ad9057d7a
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Tetali, S.R.
a0572c9c-55d8-40ac-bf62-89621772362e
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958
Kaushal, A.
cb8ef7a5-1bb3-417b-a0e0-bf37f485f294
Rezwan, F.
203f8f38-1f5d-485b-ab11-c546b4276338
Karmaus, W.
d78616d6-bc9c-4664-a461-7c0d0be5e39e
Quraishi, B.M.
512063bd-89eb-4514-8c2f-2633c1447fb7
Zhang, H.
49b0dd51-9e3e-4c73-ac6f-af1bd3a9bcd0
Everson, T.M.
cd2903f2-f8d9-4805-9d5c-0b33736130a2
Ray, M.
7f2001c1-5d01-4a81-b238-0a70f6e176e8
Lockett, G.
4d92a28c-f54c-431b-81f6-e82ad9057d7a
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Tetali, S.R.
a0572c9c-55d8-40ac-bf62-89621772362e
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958
Kaushal, A.
cb8ef7a5-1bb3-417b-a0e0-bf37f485f294
Rezwan, F.
203f8f38-1f5d-485b-ab11-c546b4276338
Karmaus, W.
d78616d6-bc9c-4664-a461-7c0d0be5e39e

Quraishi, B.M., Zhang, H., Everson, T.M., Ray, M., Lockett, G., Holloway, J.W., Tetali, S.R., Arshad, S.H., Kaushal, A., Rezwan, F. and Karmaus, W. (2015) Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation. Clinical Epigenetics, 7 (68), 1-11. (doi:10.1186/s13148-015-0108-y). (PMID:26199674)

Record type: Article

Abstract

Via epigenome-scaled analyses using recursive RF followed by log-linear models, we identified 88 CpGs associated with eczema in F1, of which 41 were replicated in F2. Several identified CpGs are located within genes in biological pathways relating to skin barrier integrity, which is central to the pathogenesis of eczema. Novel genes associated with eczema risk were identified (e.g., the PROZ and NEU1 genes).

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More information

Accepted/In Press date: 2 January 2015
Published date: 21 July 2015
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 392003
URI: https://eprints.soton.ac.uk/id/eprint/392003
ISSN: 1868-7075
PURE UUID: 68ad4e38-16b5-46ad-b5a3-bc96e2f1980d
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464
ORCID for F. Rezwan: ORCID iD orcid.org/0000-0001-9921-222X

Catalogue record

Date deposited: 13 Apr 2016 14:20
Last modified: 06 Jun 2018 12:59

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