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A microflow electrolysis cell for laboratory synthesis on the multigram scale

A microflow electrolysis cell for laboratory synthesis on the multigram scale
A microflow electrolysis cell for laboratory synthesis on the multigram scale
A large microflow electrolysis cell for laboratory synthesis on a multigram scale is described. It is based on two circular electrodes with a diameter of 149 mm and a spiral electrolyte flow channel 2000 mm long, 5 mm wide, and 0.5 mm interelectrode gap. Using the methoxylation of N-formylpyrrolidine as a model reaction, it is demonstrated that the cell approaches 100% conversion in a single pass, and it is possible to achieve a reaction selectivity >95% and a product formation rate of >20 g h–1.
1424-1427
Green, Robert A.
dd77b072-3972-4b58-921c-cce36691592f
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Pletcher, Derek
f22ebe69-b859-4a89-80b0-9e190e6f8f30
Harji, Bashir
94c4a1a5-9ece-4968-9df2-ac63ca322c62
Green, Robert A.
dd77b072-3972-4b58-921c-cce36691592f
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Pletcher, Derek
f22ebe69-b859-4a89-80b0-9e190e6f8f30
Harji, Bashir
94c4a1a5-9ece-4968-9df2-ac63ca322c62

Green, Robert A., Brown, Richard C.D., Pletcher, Derek and Harji, Bashir (2015) A microflow electrolysis cell for laboratory synthesis on the multigram scale. Organic Process Research & Development, 19 (10), 1424-1427. (doi:10.1021/acs.oprd.5b00260).

Record type: Article

Abstract

A large microflow electrolysis cell for laboratory synthesis on a multigram scale is described. It is based on two circular electrodes with a diameter of 149 mm and a spiral electrolyte flow channel 2000 mm long, 5 mm wide, and 0.5 mm interelectrode gap. Using the methoxylation of N-formylpyrrolidine as a model reaction, it is demonstrated that the cell approaches 100% conversion in a single pass, and it is possible to achieve a reaction selectivity >95% and a product formation rate of >20 g h–1.

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e-pub ahead of print date: 30 September 2015
Published date: 16 October 2015
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 392631
URI: https://eprints.soton.ac.uk/id/eprint/392631
PURE UUID: 7bdb6bdd-40d8-40e3-bc44-f9d37e7fc0de
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 14 Apr 2016 11:10
Last modified: 20 Jul 2019 01:16

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Contributors

Author: Robert A. Green
Author: Derek Pletcher
Author: Bashir Harji

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