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Dataset for Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

Dataset for Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells
Dataset for Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells
A series of fluorescent anion transporters consisting of a urea or thiourea group linked to a naphthalimide fluorophore have been synthesised and their anion transport properties studied. The compounds possess similar anion transport properties of (thio)urea-based anionophores that have previously been reported. Fluorescence studies in cells show all anionophores cross the plasma membrane and localise within the interior of cells. The most lipophilic, aromatic substituted transporters localise homogeneously throughout the cell and are toxic towards cancer cells with the highly fluorinated compound 6 being the most effective. The least lipophilic, alkyl substituted transporters localise in specific vesicles and are non-toxic to cells. This work provides new insight to the actions of anionophores in cells and may be useful in the design of novel antineoplastic agents.
University of Southampton
Berry, Stuart, Neil
c7287fbf-5845-4f28-b3ab-bf3a35e3fd9f
Soto-Cerrato, Vanessa
d14f15d9-a8f6-4a9a-9be8-f27417482712
HOWE, ETHAN NW
be05ae9a-02e0-443b-97b2-d65cc387af40
Clarke, Harriet, Jane
f5c240ce-625a-47b4-a835-8b7cb44681d2
Mistry, Ishna
ea38adfa-b415-48c2-830c-9f54f024f6cb
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Chang, Young-tae
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Pérez-Tomás, Ricardo
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Gale, Philip
c840b7e9-6847-4843-91af-fa0f8563d943
Berry, Stuart, Neil
c7287fbf-5845-4f28-b3ab-bf3a35e3fd9f
Soto-Cerrato, Vanessa
d14f15d9-a8f6-4a9a-9be8-f27417482712
HOWE, ETHAN NW
be05ae9a-02e0-443b-97b2-d65cc387af40
Clarke, Harriet, Jane
f5c240ce-625a-47b4-a835-8b7cb44681d2
Mistry, Ishna
ea38adfa-b415-48c2-830c-9f54f024f6cb
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Chang, Young-tae
2bcb59e9-b70b-495a-924b-1376bacffbdf
Pérez-Tomás, Ricardo
65d20fa5-9cc1-4a21-b7f9-56a6ec287eb7
Gale, Philip
c840b7e9-6847-4843-91af-fa0f8563d943

Berry, Stuart, Neil, Soto-Cerrato, Vanessa, HOWE, ETHAN NW, Clarke, Harriet, Jane, Mistry, Ishna, Tavassoli, Ali, Chang, Young-tae, Pérez-Tomás, Ricardo and Gale, Philip (2016) Dataset for Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells. University of Southampton doi:10.5258/SOTON/392749 [Dataset]

Record type: Dataset

Abstract

A series of fluorescent anion transporters consisting of a urea or thiourea group linked to a naphthalimide fluorophore have been synthesised and their anion transport properties studied. The compounds possess similar anion transport properties of (thio)urea-based anionophores that have previously been reported. Fluorescence studies in cells show all anionophores cross the plasma membrane and localise within the interior of cells. The most lipophilic, aromatic substituted transporters localise homogeneously throughout the cell and are toxic towards cancer cells with the highly fluorinated compound 6 being the most effective. The least lipophilic, alkyl substituted transporters localise in specific vesicles and are non-toxic to cells. This work provides new insight to the actions of anionophores in cells and may be useful in the design of novel antineoplastic agents.

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Open_Data_Source.zip - Dataset
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More information

Published date: 2016
Organisations: Chemistry, FIMS, CBDT
Projects:
Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach
Funded by: UNSPECIFIED (EP/J009687/1)
1 October 2012 to 30 September 2015

Identifiers

Local EPrints ID: 392749
URI: https://eprints.soton.ac.uk/id/eprint/392749
PURE UUID: d0da4a14-3443-4760-8ebe-7963fb8eb3d1
ORCID for Ali Tavassoli: ORCID iD orcid.org/0000-0002-7420-5063
ORCID for Philip Gale: ORCID iD orcid.org/0000-0001-9751-4910

Catalogue record

Date deposited: 19 Apr 2016 15:58
Last modified: 06 Jun 2018 12:52

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Contributors

Creator: Stuart, Neil Berry
Creator: Vanessa Soto-Cerrato
Creator: ETHAN NW HOWE
Creator: Harriet, Jane Clarke
Creator: Ishna Mistry
Creator: Ali Tavassoli ORCID iD
Creator: Young-tae Chang
Creator: Ricardo Pérez-Tomás
Creator: Philip Gale ORCID iD

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