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Tissue factor-dependent pathway in severe preeclampsia revisited

Tissue factor-dependent pathway in severe preeclampsia revisited
Tissue factor-dependent pathway in severe preeclampsia revisited
Previously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women (n = 79), normotensive pregnant women (n = 80) and women with severe P-EC (n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women (P < 0.01) or normotensive pregnant women (P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women (P < 0.01). However, no such significant trends were observed for plasma TF levels (P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity.
0957-5235
436-440
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Godoi, Lara C.
a290b120-d348-45b2-aee4-3c38dc40040f
Gomes, Karina B.
3ecaac52-151b-4740-86f9-207378d7b243
Carvalho, Maria das G.
4ac7cff6-8653-4df7-b625-0be4e52ecdd0
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Godoi, Lara C.
a290b120-d348-45b2-aee4-3c38dc40040f
Gomes, Karina B.
3ecaac52-151b-4740-86f9-207378d7b243
Carvalho, Maria das G.
4ac7cff6-8653-4df7-b625-0be4e52ecdd0
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21

Dusse, Luci M., Godoi, Lara C., Gomes, Karina B., Carvalho, Maria das G. and Lwaleed, Bashir A. (2016) Tissue factor-dependent pathway in severe preeclampsia revisited. Blood Coagulation & Fibrinolysis, 27 (4), 436-440. (doi:10.1097/MBC.0000000000000507).

Record type: Article

Abstract

Previously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women (n = 79), normotensive pregnant women (n = 80) and women with severe P-EC (n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women (P < 0.01) or normotensive pregnant women (P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women (P < 0.01). However, no such significant trends were observed for plasma TF levels (P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity.

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e-pub ahead of print date: 13 January 2016
Published date: June 2016
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 393040
URI: http://eprints.soton.ac.uk/id/eprint/393040
ISSN: 0957-5235
PURE UUID: f7adb906-8b29-4144-b6f4-4c7e552248d5

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Date deposited: 29 Jun 2016 14:28
Last modified: 14 Mar 2024 23:55

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Contributors

Author: Luci M. Dusse
Author: Lara C. Godoi
Author: Karina B. Gomes
Author: Maria das G. Carvalho

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