The activation of complement and its role in the pathogenesis of thromboembolism
The activation of complement and its role in the pathogenesis of thromboembolism
It is well established that inflammation and thrombosis are intricately linked processes, and there is increasing evidence of the importance of their roles in activated complement in the pathogenesis of thromboembolism. The two systems are activated by similar stimuli simultaneously and interact, either directly or through biochemical mediators, to protect the host from microbial invasion. Diseases characterized by complement hyperactivity such as paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome have high rates of thrombosis. This review describes how disease processes where there is excessive complement activation leads to thrombosis, and the specific interactions between the complement and coagulation systems that lead to pathological thrombus formation.
665-672
Boyce, Sara
53e3ffb0-7f21-409e-9ab6-88fdc0e15b00
Eren, Efrem
ac449fc8-4ae2-4efd-ad91-9dcea3f355e2
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
September 2015
Boyce, Sara
53e3ffb0-7f21-409e-9ab6-88fdc0e15b00
Eren, Efrem
ac449fc8-4ae2-4efd-ad91-9dcea3f355e2
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
Boyce, Sara, Eren, Efrem, Lwaleed, Bashir A. and Kazmi, Rashid S.
(2015)
The activation of complement and its role in the pathogenesis of thromboembolism.
Thrombosis and Hemostasis, 41 (6), .
(doi:10.1055/s-0035-1556732).
Abstract
It is well established that inflammation and thrombosis are intricately linked processes, and there is increasing evidence of the importance of their roles in activated complement in the pathogenesis of thromboembolism. The two systems are activated by similar stimuli simultaneously and interact, either directly or through biochemical mediators, to protect the host from microbial invasion. Diseases characterized by complement hyperactivity such as paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome have high rates of thrombosis. This review describes how disease processes where there is excessive complement activation leads to thrombosis, and the specific interactions between the complement and coagulation systems that lead to pathological thrombus formation.
This record has no associated files available for download.
More information
e-pub ahead of print date: 25 August 2015
Published date: September 2015
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 393042
URI: http://eprints.soton.ac.uk/id/eprint/393042
ISSN: 2567-689X
PURE UUID: e81e1ece-0bf2-4223-85b3-f243279ba622
Catalogue record
Date deposited: 29 Jun 2016 15:11
Last modified: 06 Aug 2024 01:39
Export record
Altmetrics
Contributors
Author:
Sara Boyce
Author:
Efrem Eren
Author:
Rashid S. Kazmi
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
