The activation of complement and its role in the pathogenesis of thromboembolism

Boyce, Sara, Eren, Efrem, Lwaleed, Bashir A. and Kazmi, Rashid S. (2015) The activation of complement and its role in the pathogenesis of thromboembolism. Thrombosis and Hemostasis, 41 (6), 665-672. (doi:10.1055/s-0035-1556732).

Record type: Article

Abstract

It is well established that inflammation and thrombosis are intricately linked processes, and there is increasing evidence of the importance of their roles in activated complement in the pathogenesis of thromboembolism. The two systems are activated by similar stimuli simultaneously and interact, either directly or through biochemical mediators, to protect the host from microbial invasion. Diseases characterized by complement hyperactivity such as paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome have high rates of thrombosis. This review describes how disease processes where there is excessive complement activation leads to thrombosis, and the specific interactions between the complement and coagulation systems that lead to pathological thrombus formation.

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