Homeostasis of hemostasis: the role of endothelium
Homeostasis of hemostasis: the role of endothelium
Forming an interface with virtually every other organ, endothelium has a strategic role in modulating vascular homeostasis. While its miscellany of functions includes regulation of vasomotor tone, promotion, and prevention of vascular growth, and modulation of inflammatory and hemostatic processes, it functions critically in maintaining the balance of hemostasis in health. Whereas endothelium has been recognized to influence all stages of hemostasis, new evidence suggests it to have a primary role for thrombin generation. Endothelial dysfunction is being increasingly appreciated in several pathological states and particularly, by virtue of its critical role in hemostasis, in causing thrombosis in a multitude of diseases.
549-555
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
Boyce, Sara
53e3ffb0-7f21-409e-9ab6-88fdc0e15b00
Lwaleed, Bashir A.
0b5ea0b9-767b-4b47-a5dd-7798e6300181
September 2015
Kazmi, Rashid S.
b31ef6bd-7f85-439d-ae28-8d097a7b8a41
Boyce, Sara
53e3ffb0-7f21-409e-9ab6-88fdc0e15b00
Lwaleed, Bashir A.
0b5ea0b9-767b-4b47-a5dd-7798e6300181
Abstract
Forming an interface with virtually every other organ, endothelium has a strategic role in modulating vascular homeostasis. While its miscellany of functions includes regulation of vasomotor tone, promotion, and prevention of vascular growth, and modulation of inflammatory and hemostatic processes, it functions critically in maintaining the balance of hemostasis in health. Whereas endothelium has been recognized to influence all stages of hemostasis, new evidence suggests it to have a primary role for thrombin generation. Endothelial dysfunction is being increasingly appreciated in several pathological states and particularly, by virtue of its critical role in hemostasis, in causing thrombosis in a multitude of diseases.
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Published date: September 2015
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 393044
URI: http://eprints.soton.ac.uk/id/eprint/393044
ISSN: 2567-689X
PURE UUID: b2c1ffdb-6acb-4e55-a18e-0123f4322ea0
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Date deposited: 28 Jun 2016 14:18
Last modified: 14 Mar 2024 23:53
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Author:
Rashid S. Kazmi
Author:
Sara Boyce
Author:
Bashir A. Lwaleed
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