Exercise-induced systemic venous hypertension in the Fontan circulation

Navaratnam, D., Fitzsimmons, S., Grocott, M., Rossiter, H.B., Emmanuel, Y., Diller, G.P., Gordon-Walker, T., Jack, S., Sheron, N., Pappachan, J., Pratap, J.N., Vettukattil, J.J. and Veldtman, G. (2016) Exercise-induced systemic venous hypertension in the Fontan circulation The American Journal of Cardiology, 117, (10), pp. 1167-1671. (doi:10.1016/j.amjcard.2016.02.042). (PMID:27032711).


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Increasingly end-organ injury is being demonstrated late after institution of the Fontan circulation, particularly liver fibrosis and cirrhosis. The exact mechanisms for these late phenomena remain largely elusive. Hypothesizing that exercise induces precipitous systemic venous hypertension and insufficient cardiac output for the exercise demand, that is, a possible mechanism for end-organ injury, we sought to demonstrate the dynamic exercise responses in systemic venous perfusion (SVP) and concurrent end-organ perfusion. Ten stable Fontan patients and 9 control subjects underwent incremental cycle ergometry-based cardiopulmonary exercise testing. SVP was monitored in the right upper limb, and regional tissue oxygen saturation was monitored in the brain and kidney using near-infrared spectroscopy. SVP rose profoundly in concert with workload in the Fontan group, described by the regression equation 15.97 + 0.073 watts per mm Hg. In contrast, SVP did not change in healthy controls. Regional renal (p <0.01) and cerebral tissue saturations (p <0.001) were significantly lower and decrease more rapidly in Fontan patients. We conclude that in a stable group of adult patients with Fontan circulation, high-intensity exercise was associated with systemic venous hypertension and reduced systemic oxygen delivery. This physiological substrate has the potential to contribute to end-organ injury.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.amjcard.2016.02.042
ISSNs: 0002-9149 (print)
Organisations: Clinical & Experimental Sciences
ePrint ID: 393680
Date :
Date Event
18 February 2016Accepted/In Press
3 March 2016e-pub ahead of print
15 May 2016Published
Date Deposited: 03 May 2016 08:53
Last Modified: 17 Apr 2017 03:18
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/393680

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