Breast cancer and the importance of early life nutrition
Breast cancer and the importance of early life nutrition
Epigenetic processes play a central role in regulating the tissue-specific expression of genes. Alterations in these processes can lead to profound changes in phenotype and have been implicated in the pathogenesis of many human diseases including human cancer. There is growing evidence that the environment, particularly variations in diet, during specific developmental periods can induce changes in the epigenome, which are then stably maintained throughout life influencing susceptibility to cancer in later life. This chapter will review the evidence that alterations in early life nutritional exposure can affect breast cancer risk through the altered epigenetic regulation of genes and discuss how detection of such altered epigenetic marks in early life may provide biomarkers to detect individuals at increased risk of disease.
269-285
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burdge, Graham C
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
11 October 2013
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burdge, Graham C
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Lillycrop, Karen A. and Burdge, Graham C
(2013)
Breast cancer and the importance of early life nutrition.
In,
Zappia, Vincenzo, Panico, Salvatore, Russo, Gian Luigi, Budillon, Alfredo and Ragione, Fulvio Della
(eds.)
Advances in Nutrition and Cancer.
(Cancer Treatment and Research, 159)
Berlin, DE.
Springer, .
(doi:10.1007/978-3-642-38007-5_16).
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Book Section
Abstract
Epigenetic processes play a central role in regulating the tissue-specific expression of genes. Alterations in these processes can lead to profound changes in phenotype and have been implicated in the pathogenesis of many human diseases including human cancer. There is growing evidence that the environment, particularly variations in diet, during specific developmental periods can induce changes in the epigenome, which are then stably maintained throughout life influencing susceptibility to cancer in later life. This chapter will review the evidence that alterations in early life nutritional exposure can affect breast cancer risk through the altered epigenetic regulation of genes and discuss how detection of such altered epigenetic marks in early life may provide biomarkers to detect individuals at increased risk of disease.
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Published date: 11 October 2013
Organisations:
Faculty of Medicine, Biomedicine
Identifiers
Local EPrints ID: 393698
URI: http://eprints.soton.ac.uk/id/eprint/393698
PURE UUID: b71f02e8-3c4b-43c3-bfdc-d17cec33cd1d
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Date deposited: 17 Jun 2016 13:23
Last modified: 15 Mar 2024 02:49
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Contributors
Editor:
Vincenzo Zappia
Editor:
Salvatore Panico
Editor:
Gian Luigi Russo
Editor:
Alfredo Budillon
Editor:
Fulvio Della Ragione
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