Searching for Drosophila Dsn1 kinetochore protein
Searching for Drosophila Dsn1 kinetochore protein
The Mis12/MIND kinetochore complex is composed of 4 subunits of which the Dsn1 protein is a crucial component in all organisms where it has been identified. In Caenorhabditis elegans, depletion of Dsn1 results in a so-called “kinetochore null” phenotype, hence Dsn1’s alternative name KNL3. In human, Dsn1 is required to shape an interface between the Mis12 complex and Blinkin, the counterpart of Spc105. In Drosophila however, despite many efforts using sequence comparisons and proteomics-based studies, a Dsn1 ortholog has not been found. Here we speculate that Drosophila Spc105R, a protein very much diverged from its counterparts in other species, might not only be playing the role of Spc105 itself but also of Dsn1.
1292-1293
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Venkei, Zsolt
0df721fd-a3e7-4360-94e2-8470bd03f487
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61
15 April 2009
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Venkei, Zsolt
0df721fd-a3e7-4360-94e2-8470bd03f487
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61
Abstract
The Mis12/MIND kinetochore complex is composed of 4 subunits of which the Dsn1 protein is a crucial component in all organisms where it has been identified. In Caenorhabditis elegans, depletion of Dsn1 results in a so-called “kinetochore null” phenotype, hence Dsn1’s alternative name KNL3. In human, Dsn1 is required to shape an interface between the Mis12 complex and Blinkin, the counterpart of Spc105. In Drosophila however, despite many efforts using sequence comparisons and proteomics-based studies, a Dsn1 ortholog has not been found. Here we speculate that Drosophila Spc105R, a protein very much diverged from its counterparts in other species, might not only be playing the role of Spc105 itself but also of Dsn1.
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Accepted/In Press date: 12 February 2009
Published date: 15 April 2009
Organisations:
Molecular and Cellular, Centre for Biological Sciences
Identifiers
Local EPrints ID: 393852
URI: http://eprints.soton.ac.uk/id/eprint/393852
ISSN: 1538-4101
PURE UUID: 9ba80d1f-8c93-4f66-ac99-27e8186c1acb
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Date deposited: 13 May 2016 15:16
Last modified: 15 Mar 2024 03:54
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Author:
Zsolt Venkei
Author:
David M. Glover
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