The kinetochore and the centromere: a working long distance relationship.
The kinetochore and the centromere: a working long distance relationship.
Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Consequently, elaborate molecular machineries and mechanisms emerged during the course of evolution in order to ensure proper division of the genetic material. The kinetochore, an essential multiprotein complex assembled on mitotic or meiotic centromeres, is an example of such machinery. Recently considerable progress has been made in understanding their composition, the recruitment hierarchy of their components, and the principles of their regulation. However, these advances are accompanied by a growing number of unanswered questions about the function of the individual subunits and of how the structure of the different subcomplexes relates to function. Here we review our rapidly growing knowledge on interacting networks of structural and regulatory proteins of the metazoan mitotic kinetochore: its centromeric foundations, its structural core, its components that interact with spindle microtubules and the spindle assembly checkpoint.
439-465
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61
December 2009
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61
Abstract
Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Consequently, elaborate molecular machineries and mechanisms emerged during the course of evolution in order to ensure proper division of the genetic material. The kinetochore, an essential multiprotein complex assembled on mitotic or meiotic centromeres, is an example of such machinery. Recently considerable progress has been made in understanding their composition, the recruitment hierarchy of their components, and the principles of their regulation. However, these advances are accompanied by a growing number of unanswered questions about the function of the individual subunits and of how the structure of the different subcomplexes relates to function. Here we review our rapidly growing knowledge on interacting networks of structural and regulatory proteins of the metazoan mitotic kinetochore: its centromeric foundations, its structural core, its components that interact with spindle microtubules and the spindle assembly checkpoint.
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e-pub ahead of print date: 24 August 2009
Published date: December 2009
Organisations:
Molecular and Cellular, Centre for Biological Sciences
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Local EPrints ID: 393864
URI: http://eprints.soton.ac.uk/id/eprint/393864
ISSN: 0066-4197
PURE UUID: edcd651d-05da-42c4-a0e2-18c99a784bb6
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Date deposited: 13 May 2016 15:45
Last modified: 15 Mar 2024 03:54
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Author:
David M. Glover
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