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Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex

Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex
Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex
Our results reveal that the Feo/Klp3A complex is necessary for Polo recruitment to the spindle midzone. A similar finding has also been recently reported in mammalian cells [1], suggesting that this basic mechanism has been conserved during evolution, albeit with some differences. Finally, since cleavage furrow formation and ingression are unaffected following feo RNAi, our data imply that Polo recruitment to the central spindle is not required for furrowing, but some other aspect of cytokinesis.
1932-6203
1-8
D'Avino, Pier Paolo
0e659e0c-c3a7-4344-8850-3364810b9445
Archambault, Vincent
3654cc6d-d3f9-4404-8ae5-9d8af8b008dc
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Lilley, Kathryn S.
84ad87ab-f75d-4686-8ab6-90fcfbdf0ec0
Laue, Ernest
7eb2721b-ca60-4b04-9c13-64bb5dec1cdb
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61
D'Avino, Pier Paolo
0e659e0c-c3a7-4344-8850-3364810b9445
Archambault, Vincent
3654cc6d-d3f9-4404-8ae5-9d8af8b008dc
Przewloka, Marcin
9b25e73c-ec15-43df-a5a4-ac9574bb20ab
Zhang, Wei
fa6d7061-bfce-48c0-879c-925302213c1a
Lilley, Kathryn S.
84ad87ab-f75d-4686-8ab6-90fcfbdf0ec0
Laue, Ernest
7eb2721b-ca60-4b04-9c13-64bb5dec1cdb
Glover, David M.
cca9cd19-3e1e-4906-b418-41876c1f9c61

D'Avino, Pier Paolo, Archambault, Vincent, Przewloka, Marcin, Zhang, Wei, Lilley, Kathryn S., Laue, Ernest and Glover, David M. (2007) Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex. PLoS ONE, 2 (6), 1-8. (doi:10.1371/journal.pone.0000572). (PMID:17593971)

Record type: Article

Abstract

Our results reveal that the Feo/Klp3A complex is necessary for Polo recruitment to the spindle midzone. A similar finding has also been recently reported in mammalian cells [1], suggesting that this basic mechanism has been conserved during evolution, albeit with some differences. Finally, since cleavage furrow formation and ingression are unaffected following feo RNAi, our data imply that Polo recruitment to the central spindle is not required for furrowing, but some other aspect of cytokinesis.

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More information

Accepted/In Press date: 2 June 2007
Published date: 27 June 2007
Organisations: Molecular and Cellular, Centre for Biological Sciences

Identifiers

Local EPrints ID: 393866
URI: http://eprints.soton.ac.uk/id/eprint/393866
ISSN: 1932-6203
PURE UUID: 6b0ae27d-db82-455b-9c84-17d161e13b44
ORCID for Marcin Przewloka: ORCID iD orcid.org/0000-0002-0329-9162

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Date deposited: 13 May 2016 15:56
Last modified: 26 Nov 2019 01:31

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