The role of DNA damage and repair in atherosclerosis: a review
The role of DNA damage and repair in atherosclerosis: a review
The global burden of cardiovascular disease is increasing despite therapeutic advances in medication and interventional technologies. Accumulated deoxyribonucleic acid (DNA) damage and subsequent repair pathways are now increasingly recognised as a causal factor in the initiation and progression of atherosclerosis. These molecular alterations have been shown to occur within affected vasculature, plaque microenvironment as well as in circulating cells. The DNA damage response (DDR) pathway is reliant on post-translational modification of sensing proteins which activate a signalling cascade to repair, if possible, DNA damaged sites in response to various environmental and physiological insults. This review summarises the current evidence for DNA damage in atherosclerosis, the key steps involved in the DDR pathway, DNA repair and their subsequent effects on atherosclerotic plaques, as well as the therapeutic options in managing DNA damage-induced atherosclerosis.
147-157
Shah, Nikunj R.
520611be-85b1-47f3-bac8-bb1f41716a9f
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
September 2015
Shah, Nikunj R.
520611be-85b1-47f3-bac8-bb1f41716a9f
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Abstract
The global burden of cardiovascular disease is increasing despite therapeutic advances in medication and interventional technologies. Accumulated deoxyribonucleic acid (DNA) damage and subsequent repair pathways are now increasingly recognised as a causal factor in the initiation and progression of atherosclerosis. These molecular alterations have been shown to occur within affected vasculature, plaque microenvironment as well as in circulating cells. The DNA damage response (DDR) pathway is reliant on post-translational modification of sensing proteins which activate a signalling cascade to repair, if possible, DNA damaged sites in response to various environmental and physiological insults. This review summarises the current evidence for DNA damage in atherosclerosis, the key steps involved in the DDR pathway, DNA repair and their subsequent effects on atherosclerotic plaques, as well as the therapeutic options in managing DNA damage-induced atherosclerosis.
This record has no associated files available for download.
More information
Accepted/In Press date: 8 July 2015
e-pub ahead of print date: 26 July 2015
Published date: September 2015
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 394526
URI: http://eprints.soton.ac.uk/id/eprint/394526
PURE UUID: 7b27b9e1-0aad-4875-80c6-8dd6e1cdf869
Catalogue record
Date deposited: 20 May 2016 08:33
Last modified: 15 Mar 2024 03:54
Export record
Altmetrics
Contributors
Author:
Nikunj R. Shah
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
