The left atrial appendage in health and disease
The left atrial appendage in health and disease
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmiaand results in significant morbidity and mortality. The left atrial appendage (LAA), a small embryonic remnant of the left atrium (LA), has been shown to play a key role in the pathophysiology of AF-related stroke and thromboembolism. As a consequence the LAA, in spite of its meagre size, has been described as ‘our most lethal human attachment’. Despite being a recognised harbinger of disease, the LAA has also been shown to play an important role in health. This review seeks to address our current understanding of this vital structure in both health and disease states.
1-3
Howlett, Philippa J.
722ac7d9-5c20-478c-84eb-afddf1fdaf7d
Shah, Nikunj R.
520611be-85b1-47f3-bac8-bb1f41716a9f
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
23 July 2015
Howlett, Philippa J.
722ac7d9-5c20-478c-84eb-afddf1fdaf7d
Shah, Nikunj R.
520611be-85b1-47f3-bac8-bb1f41716a9f
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Howlett, Philippa J., Shah, Nikunj R. and Mahmoudi, Michael
(2015)
The left atrial appendage in health and disease.
MOJ Anatomy & Physiology, 1 (1), .
(doi:10.15406/mojap.2015.01.00004).
Abstract
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmiaand results in significant morbidity and mortality. The left atrial appendage (LAA), a small embryonic remnant of the left atrium (LA), has been shown to play a key role in the pathophysiology of AF-related stroke and thromboembolism. As a consequence the LAA, in spite of its meagre size, has been described as ‘our most lethal human attachment’. Despite being a recognised harbinger of disease, the LAA has also been shown to play an important role in health. This review seeks to address our current understanding of this vital structure in both health and disease states.
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MOJAP-01-00004.pdf
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Published date: 23 July 2015
Organisations:
Human Development & Health
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Local EPrints ID: 394538
URI: http://eprints.soton.ac.uk/id/eprint/394538
ISSN: 2471-139X
PURE UUID: be6512a6-1f2c-4146-bef4-6755c0754844
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Date deposited: 25 May 2016 13:11
Last modified: 15 Mar 2024 03:54
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Author:
Philippa J. Howlett
Author:
Nikunj R. Shah
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