Ischemic preconditioning—an unfulfilled promise
Ischemic preconditioning—an unfulfilled promise
Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac interventions have produced mixed results. Ischemic conditioning has been applied before, during, or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. Clinical studies have confirmed the safety of differing conditioning techniques, but the benefit of such techniques in reducing hard clinical event rates has produced mixed results. The aim of this article is to review the role of ischemic conditioning in patients undergoing percutaneous and surgical coronary revascularization.
101-108
Williams, Timothy M.
afc0a4c6-33c7-4e8f-a7de-5a3b7b592d23
Waksman, Ron
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De Silva, Kalpa
61097142-a3b4-4264-86ba-1f2311261675
Jacques, Adam
39cd1e9c-4fed-49be-946a-93b66afd5608
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
March 2015
Williams, Timothy M.
afc0a4c6-33c7-4e8f-a7de-5a3b7b592d23
Waksman, Ron
23d6bf65-0556-4930-8fad-224a559b34e0
De Silva, Kalpa
61097142-a3b4-4264-86ba-1f2311261675
Jacques, Adam
39cd1e9c-4fed-49be-946a-93b66afd5608
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Williams, Timothy M., Waksman, Ron, De Silva, Kalpa, Jacques, Adam and Mahmoudi, Michael
(2015)
Ischemic preconditioning—an unfulfilled promise.
Cardiovascular Revascularization Medicine, 16 (2), .
(doi:10.1016/j.carrev.2014.12.010).
(PMID:25681256)
Abstract
Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac interventions have produced mixed results. Ischemic conditioning has been applied before, during, or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. Clinical studies have confirmed the safety of differing conditioning techniques, but the benefit of such techniques in reducing hard clinical event rates has produced mixed results. The aim of this article is to review the role of ischemic conditioning in patients undergoing percutaneous and surgical coronary revascularization.
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Accepted/In Press date: 18 December 2014
e-pub ahead of print date: 26 December 2014
Published date: March 2015
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 394541
URI: http://eprints.soton.ac.uk/id/eprint/394541
ISSN: 1553-8389
PURE UUID: 695fd1b6-83aa-4518-9594-4394d45d5de6
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Date deposited: 25 May 2016 13:13
Last modified: 15 Mar 2024 03:54
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Author:
Timothy M. Williams
Author:
Ron Waksman
Author:
Kalpa De Silva
Author:
Adam Jacques
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