Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence
Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence
Background: Animal studies have demonstrated poor cognitive outcomes in offspring in relation to maternal vitamin D deficiency before and/or during pregnancy. Human studies linking maternal vitamin D status during pregnancy with offspring cognitive function are limited. We aimed to test the hypothesis that lower maternal vitamin D status during pregnancy is associated with poor offspring cognitive ability in an Indian population.
Methods: Cognitive function was assessed in children from the Mysore Parthenon birth cohort during childhood (age 9-10 years; n=468) and adolescence (age 13-14 years; n=472) using 3 core tests from the Kaufman Assessment Battery for children and additional tests measuring learning, long-term retrieval/storage, short-term memory, reasoning, verbal fluency, visuo-spatial ability, and attention and concentration. Maternal serum 25-hydroxyvitamin D concentration was measured at 30±2 weeks of gestation.
Results: During pregnancy 320 (68%) women had ‘vitamin D deficiency’ (serum 25-hydroxyvitamin D concentration <50 nmol/L). Girls scored better than boys in tests of short-term memory, reasoning, verbal fluency, and attention (p<0.05 for all). Maternal vitamin D status (low as well as across the entire range) was unrelated to offspring cognitive function at both ages, either unadjusted or after adjustment for the child’s current age, sex, maternal age, parity, season at the time of blood sampling, gestational age, the child’s birth and current size, socio-economic status, parents’ education, maternal intelligence and home environment.
Conclusions: In this population, despite a high prevalence of vitamin D deficiency during pregnancy, there was no evidence of an association between maternal vitamin D status and offspring cognitive function.
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Veena, S.R.
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Krishnaveni, G.V.
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Srinivasan, K.
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Thajna, K.P.
b4092626-3d82-4c6d-ade8-037ce4f7dcf0
Hedge, B.G.
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Gale, C.R.
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Fall, C.H.D.
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Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Srinivasan, K.
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Thajna, K.P.
b4092626-3d82-4c6d-ade8-037ce4f7dcf0
Hedge, B.G.
d84d741f-878b-4759-b134-ec834e3c8f8a
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Veena, S.R., Krishnaveni, G.V., Srinivasan, K., Thajna, K.P., Hedge, B.G., Gale, C.R. and Fall, C.H.D.
(2016)
Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence.
Asia Pacific Journal of Clinical Nutrition, .
(In Press)
Abstract
Background: Animal studies have demonstrated poor cognitive outcomes in offspring in relation to maternal vitamin D deficiency before and/or during pregnancy. Human studies linking maternal vitamin D status during pregnancy with offspring cognitive function are limited. We aimed to test the hypothesis that lower maternal vitamin D status during pregnancy is associated with poor offspring cognitive ability in an Indian population.
Methods: Cognitive function was assessed in children from the Mysore Parthenon birth cohort during childhood (age 9-10 years; n=468) and adolescence (age 13-14 years; n=472) using 3 core tests from the Kaufman Assessment Battery for children and additional tests measuring learning, long-term retrieval/storage, short-term memory, reasoning, verbal fluency, visuo-spatial ability, and attention and concentration. Maternal serum 25-hydroxyvitamin D concentration was measured at 30±2 weeks of gestation.
Results: During pregnancy 320 (68%) women had ‘vitamin D deficiency’ (serum 25-hydroxyvitamin D concentration <50 nmol/L). Girls scored better than boys in tests of short-term memory, reasoning, verbal fluency, and attention (p<0.05 for all). Maternal vitamin D status (low as well as across the entire range) was unrelated to offspring cognitive function at both ages, either unadjusted or after adjustment for the child’s current age, sex, maternal age, parity, season at the time of blood sampling, gestational age, the child’s birth and current size, socio-economic status, parents’ education, maternal intelligence and home environment.
Conclusions: In this population, despite a high prevalence of vitamin D deficiency during pregnancy, there was no evidence of an association between maternal vitamin D status and offspring cognitive function.
Text
Veena et al_VitD_CF_APJCN final accepted.doc
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More information
Accepted/In Press date: 2 May 2016
Organisations:
MRC Life-Course Epidemiology Unit
Identifiers
Local EPrints ID: 394544
URI: http://eprints.soton.ac.uk/id/eprint/394544
ISSN: 0964-7058
PURE UUID: 32ce6d99-9ffc-44fb-b918-e28a80484d13
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Date deposited: 20 May 2016 11:03
Last modified: 15 Mar 2024 05:34
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Contributors
Author:
S.R. Veena
Author:
G.V. Krishnaveni
Author:
K. Srinivasan
Author:
K.P. Thajna
Author:
B.G. Hedge
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