Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy

Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P=0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio (P=0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher (P=0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377.

10.1016/j.plefa.2016.05.006

35-41

Malan, L

851be147-9fe3-4e31-819e-f49236445900

Baumgartner, J

977cba81-3844-4c93-8eff-428e7a82e936

Calder, P.C.

1797e54f-378e-4dcb-80a4-3e30018f07a6

Smuts, CM

f04a7fd2-9b92-43c2-a378-7357e788739e

July 2016

Malan, L

851be147-9fe3-4e31-819e-f49236445900

Baumgartner, J

977cba81-3844-4c93-8eff-428e7a82e936

Calder, P.C.

1797e54f-378e-4dcb-80a4-3e30018f07a6

Smuts, CM

f04a7fd2-9b92-43c2-a378-7357e788739e

Malan, L, Baumgartner, J, Calder, P.C. and Smuts, CM (2016) Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy. Prostaglandins, Leukotrienes and Essential Fatty Acids, 110, 35-41. (doi:10.1016/j.plefa.2016.05.006).

Record type: Article

Abstract

Text

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Malan et al_ Fatty acids and allergy__reviewed for PLEFA 04052016.pdf - Accepted Manuscript

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (145kB)

Image

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Supplemental Fig. 1.1 Lipid mediator chromatogram all.png - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (190kB)

Image

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Supplemental Fig. 1.2 Lipid mediator chromatogram_prostaglandins.png - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (167kB)

Image

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Supplemental Fig. 1.3 Lipid mediator chromatogram_HEPE and 17HDHA.png - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (159kB)

Image

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Supplemental Fig. 1.4 Lipid mediator chromatogram_HETE.png - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (190kB)

Text

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Malan et al Fig. 1.pdf - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (85kB)

Text

__soton.ac.uk_ude_PersonalFiles_Users_lce_mydocuments_Eprints - Prof Calder_Accepted publications for eprints_Malan et al. Fig. 2.pdf - Other

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (40kB)

Show all 7 downloads.