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Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy

Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy
Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy
Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P=0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio (P=0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher (P=0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377.
35-41
Malan, L
851be147-9fe3-4e31-819e-f49236445900
Baumgartner, J
977cba81-3844-4c93-8eff-428e7a82e936
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Smuts, CM
f04a7fd2-9b92-43c2-a378-7357e788739e
Malan, L
851be147-9fe3-4e31-819e-f49236445900
Baumgartner, J
977cba81-3844-4c93-8eff-428e7a82e936
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Smuts, CM
f04a7fd2-9b92-43c2-a378-7357e788739e

Malan, L, Baumgartner, J, Calder, P.C. and Smuts, CM (2016) Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy. Prostaglandins, Leukotrienes and Essential Fatty Acids, 110, 35-41. (doi:10.1016/j.plefa.2016.05.006).

Record type: Article

Abstract

Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with parent-reported allergy data were divided into an allergic (n=30) and non-allergic (n=81) group and compared. PBMC arachidonic acid (ARA; P=0.010) and the PBMC ARA to dihomo-gamma-linolenic acid (DGLA) ratio (P=0.035) were lower in the allergic children. Plasma 12-hydroxyeicosatetraenoic acid and 17-hydroxydocosahexaenoic acid (17-HDHA) were higher (P=0.040 and 0.020, respectively) in the allergic group. Thus, a fatty acid composition and lipid mediator levels indicative of increased release of ARA from PBMC membranes, increased inflammation as well as the resolving thereof, were associated with parent-reported allergy symptoms. This study used baseline data of an intervention study which was registered at clinicaltrials.gov as NCT01092377.

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More information

Accepted/In Press date: 11 May 2016
e-pub ahead of print date: 13 May 2016
Published date: July 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 394639
URI: http://eprints.soton.ac.uk/id/eprint/394639
PURE UUID: acf3496f-5166-4eef-a63d-26af10212245
ORCID for P.C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 23 May 2016 08:42
Last modified: 11 Mar 2021 02:35

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