Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro
Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl– transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro.
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Share, Andrew I.
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Patel, Khushali
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Nativi, Cristina
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Cho, Eun-Jeong
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Francesconi, Oscar
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Busschaert, Nathalie
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Gale, Philip A.
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Roelens, Stefano
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Sessler, Jonathan L.
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Share, Andrew I.
af499cf6-2546-4b32-af27-6548fb21b8ee
Patel, Khushali
6fcd5bd1-beb2-4c77-badb-f05f12d5ac41
Nativi, Cristina
5478d409-183a-4c31-b9fd-4691bec47cbf
Cho, Eun-Jeong
a4e88d4c-ea0a-4766-b60f-0d09397dcd74
Francesconi, Oscar
ec1dd840-ec6d-45f8-a7e4-4c9c010d02f2
Busschaert, Nathalie
bf307f09-0a86-4a03-afd8-4b0a59a8f72b
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943
Roelens, Stefano
f20ef224-d735-40ca-a524-2a0e48ddb7fa
Sessler, Jonathan L.
d793ea76-a3a2-4ce1-a8d5-aca7d3307fbe
Share, Andrew I., Patel, Khushali, Nativi, Cristina, Cho, Eun-Jeong, Francesconi, Oscar, Busschaert, Nathalie, Gale, Philip A., Roelens, Stefano and Sessler, Jonathan L.
(2016)
Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
Chemical Communications, .
(doi:10.1039/C6CC03645G).
Abstract
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl– transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro.
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Accepted/In Press date: 18 May 2016
e-pub ahead of print date: 18 May 2016
Organisations:
Organic Chemistry: SCF
Identifiers
Local EPrints ID: 394755
URI: http://eprints.soton.ac.uk/id/eprint/394755
ISSN: 1359-7345
PURE UUID: 1459eadd-83fe-4c8d-95e5-3a27f3303fbe
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Date deposited: 23 May 2016 15:36
Last modified: 15 Mar 2024 05:35
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Contributors
Author:
Andrew I. Share
Author:
Khushali Patel
Author:
Cristina Nativi
Author:
Eun-Jeong Cho
Author:
Oscar Francesconi
Author:
Nathalie Busschaert
Author:
Philip A. Gale
Author:
Stefano Roelens
Author:
Jonathan L. Sessler
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