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NIDDK international conference report on diabetes and depression: current understanding and future directions

NIDDK international conference report on diabetes and depression: current understanding and future directions
NIDDK international conference report on diabetes and depression: current understanding and future directions
Comorbid diabetes and depression are a major clinical challenge as the outcomes of each condition are worsened by the other. This article is based on the presentations and discussions during an international meeting on diabetes and depression convened by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in collaboration with the National Institute of Mental Health and the Dialogue on Diabetes and Depression. While the psychological burden of diabetes may contribute to depression in some cases, this explanation does not sufficiently explain the relationship between these two conditions. Shared biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, autonomic dysfunction, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors, are important to consider in understanding the link between depression and diabetes. Both individual psychological and pharmacological depression treatments are effective in people with diabetes, but the current range of treatment options is limited and has shown mixed effects on glycemic outcomes. More research is needed to understand what factors contribute to individual differences in vulnerability, treatment response, and resilience to depression and metabolic disorders across the life course and how best to provide care for people with comorbid diabetes and depression in different health care settings. Training programs are needed to create a cross-disciplinary workforce that can work in different models of care for comorbid conditions
1935-5548
2067-2077
Holt, Richard
d54202e1-fcf6-4a17-a320-9f32d7024393
de Groot, M.
931affe2-dda6-4588-9f2d-21d592500f06
Lucki, I.
6df78820-3f7a-493c-82cd-25e0932962cc
Hunter, C.M.
d244c7fd-4f49-47bf-8ab5-8d512f3f4ee1
Sartorius, N.
1d07d5ad-26c3-48e7-b7c7-52120bf89222
Golden, S.H.
702aceba-498f-4124-b604-b70483d1ef4c
Holt, Richard
d54202e1-fcf6-4a17-a320-9f32d7024393
de Groot, M.
931affe2-dda6-4588-9f2d-21d592500f06
Lucki, I.
6df78820-3f7a-493c-82cd-25e0932962cc
Hunter, C.M.
d244c7fd-4f49-47bf-8ab5-8d512f3f4ee1
Sartorius, N.
1d07d5ad-26c3-48e7-b7c7-52120bf89222
Golden, S.H.
702aceba-498f-4124-b604-b70483d1ef4c

Holt, Richard, de Groot, M., Lucki, I., Hunter, C.M., Sartorius, N. and Golden, S.H. (2014) NIDDK international conference report on diabetes and depression: current understanding and future directions. Diabetes Care, 37 (8), 2067-2077. (doi:10.2337/dc13-2134). (PMID:25061135)

Record type: Article

Abstract

Comorbid diabetes and depression are a major clinical challenge as the outcomes of each condition are worsened by the other. This article is based on the presentations and discussions during an international meeting on diabetes and depression convened by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in collaboration with the National Institute of Mental Health and the Dialogue on Diabetes and Depression. While the psychological burden of diabetes may contribute to depression in some cases, this explanation does not sufficiently explain the relationship between these two conditions. Shared biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, autonomic dysfunction, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors, are important to consider in understanding the link between depression and diabetes. Both individual psychological and pharmacological depression treatments are effective in people with diabetes, but the current range of treatment options is limited and has shown mixed effects on glycemic outcomes. More research is needed to understand what factors contribute to individual differences in vulnerability, treatment response, and resilience to depression and metabolic disorders across the life course and how best to provide care for people with comorbid diabetes and depression in different health care settings. Training programs are needed to create a cross-disciplinary workforce that can work in different models of care for comorbid conditions

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NIH conference report paper 09092013.docx - Accepted Manuscript
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Accepted/In Press date: 14 April 2014
Published date: August 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 394812
URI: http://eprints.soton.ac.uk/id/eprint/394812
ISSN: 1935-5548
PURE UUID: dd678af4-44f8-4519-8a99-6b6eafd28f7f
ORCID for Richard Holt: ORCID iD orcid.org/0000-0001-8911-6744

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Date deposited: 20 May 2016 10:59
Last modified: 18 Feb 2021 16:56

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Contributors

Author: Richard Holt ORCID iD
Author: M. de Groot
Author: I. Lucki
Author: C.M. Hunter
Author: N. Sartorius
Author: S.H. Golden

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