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Sleep in children with attention-deficit/hyperactivity disorder (ADHD) before and after 6-month treatment with methylphenidate: a pilot study

Sleep in children with attention-deficit/hyperactivity disorder (ADHD) before and after 6-month treatment with methylphenidate: a pilot study
Sleep in children with attention-deficit/hyperactivity disorder (ADHD) before and after 6-month treatment with methylphenidate: a pilot study
Children with ADHD may present with sleep disturbances that add to the impairment of the disorder. The long-term sleep effects of the first-line pharmacological treatment for ADHD, i.e., psychostimulants, are unclear. In this pilot study, we compared polysomnographic variables in children with ADHD (n?=?11, aged 6–15 years), before pharmacological treatment, and in children without ADHD (n?=?22, aged 5–14 years); we also assessed polysomnographic changes in children with ADHD (n?=?7) after a 6-month treatment with methylphenidate immediate-release (once or twice daily). Compared to children without ADHD, those with ADHD at baseline presented with significantly increased duration of awakenings (p?=?0.02), reduction in sleep efficiency (p?=?0.03), and increase in stage I (N1) (p?<?0.01) and reduction in stage II (N2) (p?=?0.02) and stage III–IV (N3) percentages. Methylphenidate treatment did not significantly change any parameter of sleep architecture.
Conclusion: Preliminary evidence from this pilot study shows that, compared to children without ADHD, those with ADHD presented a more fragmented and less effective sleep at baseline and that the 6-month methylphenidate treatment did not further negatively impact on sleep architecture.
0340-6199
695-704
Vigliano, Piernanda
0d52a87c-1a05-4f9b-8b76-c1a7ec16cc8e
Galloni, Giovanni Battista
cc55a184-fdf4-4d52-a7e5-bcf40c8592cd
Bagnasco, Irene
22214ec0-1e75-4746-b3ad-24bda3094b76
Delia, Giuliana
966d4afc-c8c6-4496-a245-119db014a685
Moletto, Alessandra
59e19e33-b09e-47c9-9e2e-d2142512ae3a
Mana, Mauro
33a4690c-484a-4f32-850e-d82f899ce24a
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Vigliano, Piernanda
0d52a87c-1a05-4f9b-8b76-c1a7ec16cc8e
Galloni, Giovanni Battista
cc55a184-fdf4-4d52-a7e5-bcf40c8592cd
Bagnasco, Irene
22214ec0-1e75-4746-b3ad-24bda3094b76
Delia, Giuliana
966d4afc-c8c6-4496-a245-119db014a685
Moletto, Alessandra
59e19e33-b09e-47c9-9e2e-d2142512ae3a
Mana, Mauro
33a4690c-484a-4f32-850e-d82f899ce24a
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb

Vigliano, Piernanda, Galloni, Giovanni Battista, Bagnasco, Irene, Delia, Giuliana, Moletto, Alessandra, Mana, Mauro and Cortese, Samuele (2016) Sleep in children with attention-deficit/hyperactivity disorder (ADHD) before and after 6-month treatment with methylphenidate: a pilot study. European Journal of Pediatrics, 175 (5), 695-704. (doi:10.1007/s00431-016-2695-9).

Record type: Article

Abstract

Children with ADHD may present with sleep disturbances that add to the impairment of the disorder. The long-term sleep effects of the first-line pharmacological treatment for ADHD, i.e., psychostimulants, are unclear. In this pilot study, we compared polysomnographic variables in children with ADHD (n?=?11, aged 6–15 years), before pharmacological treatment, and in children without ADHD (n?=?22, aged 5–14 years); we also assessed polysomnographic changes in children with ADHD (n?=?7) after a 6-month treatment with methylphenidate immediate-release (once or twice daily). Compared to children without ADHD, those with ADHD at baseline presented with significantly increased duration of awakenings (p?=?0.02), reduction in sleep efficiency (p?=?0.03), and increase in stage I (N1) (p?<?0.01) and reduction in stage II (N2) (p?=?0.02) and stage III–IV (N3) percentages. Methylphenidate treatment did not significantly change any parameter of sleep architecture.
Conclusion: Preliminary evidence from this pilot study shows that, compared to children without ADHD, those with ADHD presented a more fragmented and less effective sleep at baseline and that the 6-month methylphenidate treatment did not further negatively impact on sleep architecture.

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More information

Accepted/In Press date: 19 January 2016
e-pub ahead of print date: 30 January 2016
Published date: May 2016
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 394820
URI: http://eprints.soton.ac.uk/id/eprint/394820
ISSN: 0340-6199
PURE UUID: 15eb1e53-3cad-43a9-bf4b-a1e9b72bd946
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 24 May 2016 11:39
Last modified: 15 Mar 2024 03:52

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Contributors

Author: Piernanda Vigliano
Author: Giovanni Battista Galloni
Author: Irene Bagnasco
Author: Giuliana Delia
Author: Alessandra Moletto
Author: Mauro Mana
Author: Samuele Cortese ORCID iD

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