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Liposome production by microfluidics: potential and limiting factors

Liposome production by microfluidics: potential and limiting factors
Liposome production by microfluidics: potential and limiting factors
This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.
1-15
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Bottaro, Elisabetta
646a9ca9-bfc7-477f-a5e7-63732d9f04fa
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6
Nastruzzi, Claudio
fa760f44-1546-4aa2-838d-242a908ea463
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Bottaro, Elisabetta
646a9ca9-bfc7-477f-a5e7-63732d9f04fa
Owen, Joshua
b5d9c311-b8d4-40db-b937-65a769a11b4f
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6
Nastruzzi, Claudio
fa760f44-1546-4aa2-838d-242a908ea463

Carugo, Dario, Bottaro, Elisabetta, Owen, Joshua, Stride, Eleanor and Nastruzzi, Claudio (2016) Liposome production by microfluidics: potential and limiting factors. Scientific Reports, 6 (25876), 1-15. (doi:10.1038/srep25876).

Record type: Article

Abstract

This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.

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More information

Accepted/In Press date: 22 April 2016
e-pub ahead of print date: 19 May 2016
Organisations: Bioengineering Group, Mechatronics

Identifiers

Local EPrints ID: 394836
URI: https://eprints.soton.ac.uk/id/eprint/394836
PURE UUID: e7e57eba-0acc-40d0-b885-629c23b20813

Catalogue record

Date deposited: 24 May 2016 14:30
Last modified: 09 Jan 2018 18:06

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