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Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study

Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g XOS+109 CFU Bi-07/d) was given to healthy adults (25–65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d (P= 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality (P= 0·003) and happiness (P= 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period (P= 0·004). XOS supplementation significantly increased faecal bifidobacterial counts (P= 0·008) and fasting plasma HDL concentrations (P= 0·005). Bi-07 supplementation significantly increased faecal B. lactis content (P= 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures (P= 0·035) and salivary IgA content (P= 0·040) and increased IL-6 secretion (P= 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells (P= 0·027) and lower IL-10 secretion (P= 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07, P= 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut microbiota and markers of immune function.
0007-1145
1945-1956
Childs, Caroline
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Röytiö, Henna
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Alhoniemi, Esa
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Fekete, Agnes A.
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Forssten, Sofia D.
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Hudjec, Natasa
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Lim, Ying Ni
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Steger, Cara J.
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Yaqoob, Parveen
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Tuohy, Kieran M.
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Rastall, Robert A.
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Ouwehand, Arthur C.
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Gibson, Glenn R.
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Childs, Caroline
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Röytiö, Henna
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Alhoniemi, Esa
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Fekete, Agnes A.
e09ec361-455c-497b-a8f8-d3dbccb5ff69
Forssten, Sofia D.
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Hudjec, Natasa
322e6502-e558-46bc-b33f-9682c1a1da9b
Lim, Ying Ni
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Steger, Cara J.
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Yaqoob, Parveen
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Tuohy, Kieran M.
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Rastall, Robert A.
c8c930d7-f2d4-4af6-adf2-ed71e8b1992f
Ouwehand, Arthur C.
b3fdeef6-9ce4-4311-88a7-46fdfcd7a4d3
Gibson, Glenn R.
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Childs, Caroline, Röytiö, Henna, Alhoniemi, Esa, Fekete, Agnes A., Forssten, Sofia D., Hudjec, Natasa, Lim, Ying Ni, Steger, Cara J., Yaqoob, Parveen, Tuohy, Kieran M., Rastall, Robert A., Ouwehand, Arthur C. and Gibson, Glenn R. (2014) Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study. British Journal of Nutrition, 111 (11), 1945-1956. (doi:10.1017/S0007114513004261).

Record type: Article

Abstract

Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g XOS+109 CFU Bi-07/d) was given to healthy adults (25–65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d (P= 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality (P= 0·003) and happiness (P= 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period (P= 0·004). XOS supplementation significantly increased faecal bifidobacterial counts (P= 0·008) and fasting plasma HDL concentrations (P= 0·005). Bi-07 supplementation significantly increased faecal B. lactis content (P= 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures (P= 0·035) and salivary IgA content (P= 0·040) and increased IL-6 secretion (P= 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells (P= 0·027) and lower IL-10 secretion (P= 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07, P= 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut microbiota and markers of immune function.

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Submitted date: 12 April 2013
Accepted/In Press date: 29 November 2013
e-pub ahead of print date: 24 March 2014
Published date: 24 March 2014
Organisations: Faculty of Medicine, Human Development & Health

Identifiers

Local EPrints ID: 394848
URI: http://eprints.soton.ac.uk/id/eprint/394848
ISSN: 0007-1145
PURE UUID: 592d74d8-39c6-4f94-b40b-304b5dc444c5
ORCID for Caroline Childs: ORCID iD orcid.org/0000-0001-6832-224X

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Date deposited: 24 May 2016 15:36
Last modified: 28 Apr 2022 02:00

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Contributors

Author: Caroline Childs ORCID iD
Author: Henna Röytiö
Author: Esa Alhoniemi
Author: Agnes A. Fekete
Author: Sofia D. Forssten
Author: Natasa Hudjec
Author: Ying Ni Lim
Author: Cara J. Steger
Author: Parveen Yaqoob
Author: Kieran M. Tuohy
Author: Robert A. Rastall
Author: Arthur C. Ouwehand
Author: Glenn R. Gibson

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