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Periodontitis and cognitive decline in Alzheimer's disease.

Periodontitis and cognitive decline in Alzheimer's disease.
Periodontitis and cognitive decline in Alzheimer's disease.
Periodontitis is common in the elderly and may become more common in Alzheimer's disease because of a reduced ability to take care of oral hygiene as the disease progresses. Elevated antibodies to periodontal bacteria are associated with an increased systemic pro-inflammatory state. Elsewhere raised serum pro-inflammatory cytokines have been associated with an increased rate of cognitive decline in Alzheimer's disease. We hypothesized that periodontitis would be associated with increased dementia severity and a more rapid cognitive decline in Alzheimer's disease. We aimed to determine if periodontitis in Alzheimer's disease is associated with both increased dementia severity and cognitive decline, and an increased systemic pro inflammatory state. In a six month observational cohort study 60 community dwelling participants with mild to moderate Alzheimer's Disease were cognitively assessed and a blood sample taken for systemic inflammatory markers. Dental health was assessed by a dental hygienist, blind to cognitive outcomes. All assessments were repeated at six months. The presence of periodontitis at baseline was not related to baseline cognitive state but was associated with a six fold increase in the rate of cognitive decline as assessed by the ADAS-cog over a six month follow up period. Periodontitis at baseline was associated with a relative increase in the pro-inflammatory state over the six month follow up period. Our data showed that periodontitis is associated with an increase in cognitive decline in Alzheimer's Disease, independent to baseline cognitive state, which may be mediated through effects on systemic inflammation.
1932-6203
1-9
Ide, Mark
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Harris, Marina
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Stevens, Annette
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Sussams, Rebecca
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Hopkins, Viv
829ba764-ef18-43d1-8ac1-29edd7da7f1b
Culliford, David
25511573-74d3-422a-b0ee-dfe60f80df87
Fuller, James
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Ibbett, Paul
bac07548-e35f-4f01-89c1-71b3404aa4e4
Raybould, Rachel
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Thomas, Rhodri
f53e5e89-7652-4fb8-be75-0c3894f38846
Puenter, Ursula
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Teeling, Jessica
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Perry, V. Hugh
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Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Ide, Mark
aa4a27a1-7c6b-491c-a42d-16337a8d0c11
Harris, Marina
734bf0bc-c325-4f67-8c9f-4270186f4f87
Stevens, Annette
221bbee1-1ef9-4c37-b70a-1b8cd724b727
Sussams, Rebecca
7730c148-943d-4d97-b3c4-02e157bcc178
Hopkins, Viv
829ba764-ef18-43d1-8ac1-29edd7da7f1b
Culliford, David
25511573-74d3-422a-b0ee-dfe60f80df87
Fuller, James
1cc7f516-492a-4cd4-ad6b-854045ad81fe
Ibbett, Paul
bac07548-e35f-4f01-89c1-71b3404aa4e4
Raybould, Rachel
e50082d7-12bb-4e64-8cc7-0a3ec3e71431
Thomas, Rhodri
f53e5e89-7652-4fb8-be75-0c3894f38846
Puenter, Ursula
44e14401-cc8e-4124-b8b9-1f32cc6315dc
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96

Ide, Mark, Harris, Marina, Stevens, Annette, Sussams, Rebecca, Hopkins, Viv, Culliford, David, Fuller, James, Ibbett, Paul, Raybould, Rachel, Thomas, Rhodri, Puenter, Ursula, Teeling, Jessica, Perry, V. Hugh and Holmes, Clive (2016) Periodontitis and cognitive decline in Alzheimer's disease. PLoS ONE, 11 (3), 1-9. (doi:10.1371/journal.pone.0151081). (PMID:26963387)

Record type: Article

Abstract

Periodontitis is common in the elderly and may become more common in Alzheimer's disease because of a reduced ability to take care of oral hygiene as the disease progresses. Elevated antibodies to periodontal bacteria are associated with an increased systemic pro-inflammatory state. Elsewhere raised serum pro-inflammatory cytokines have been associated with an increased rate of cognitive decline in Alzheimer's disease. We hypothesized that periodontitis would be associated with increased dementia severity and a more rapid cognitive decline in Alzheimer's disease. We aimed to determine if periodontitis in Alzheimer's disease is associated with both increased dementia severity and cognitive decline, and an increased systemic pro inflammatory state. In a six month observational cohort study 60 community dwelling participants with mild to moderate Alzheimer's Disease were cognitively assessed and a blood sample taken for systemic inflammatory markers. Dental health was assessed by a dental hygienist, blind to cognitive outcomes. All assessments were repeated at six months. The presence of periodontitis at baseline was not related to baseline cognitive state but was associated with a six fold increase in the rate of cognitive decline as assessed by the ADAS-cog over a six month follow up period. Periodontitis at baseline was associated with a relative increase in the pro-inflammatory state over the six month follow up period. Our data showed that periodontitis is associated with an increase in cognitive decline in Alzheimer's Disease, independent to baseline cognitive state, which may be mediated through effects on systemic inflammation.

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Accepted/In Press date: 23 February 2016
Published date: 10 March 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 395336
URI: https://eprints.soton.ac.uk/id/eprint/395336
ISSN: 1932-6203
PURE UUID: 581e385b-575c-4563-8a80-e1b98bed16db
ORCID for David Culliford: ORCID iD orcid.org/0000-0003-1663-0253
ORCID for Jessica Teeling: ORCID iD orcid.org/0000-0003-4004-7391
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

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Date deposited: 27 May 2016 10:54
Last modified: 10 Dec 2019 01:50

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Contributors

Author: Mark Ide
Author: Marina Harris
Author: Annette Stevens
Author: Rebecca Sussams
Author: Viv Hopkins
Author: David Culliford ORCID iD
Author: James Fuller
Author: Paul Ibbett
Author: Rachel Raybould
Author: Rhodri Thomas
Author: Ursula Puenter
Author: Jessica Teeling ORCID iD
Author: V. Hugh Perry
Author: Clive Holmes ORCID iD

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