Cell signalling during blastocyst morphogenesis
Cell signalling during blastocyst morphogenesis
Blastocyst morphogenesis is prepared for even before fertilisation. Information stored within parental gametes can influence both maternal and embryonic gene expression programmes after egg activation at fertilisation. A complex network of intrinsic, cell-cell mediated and extrinsic, embryo-environment signalling mechanisms operates throughout cleavage, compaction and cavitation. These signalling events not only ensure developmental progression, cell differentiation and lineage allocation to inner cell mass (embryo proper) and trophectoderm (future extraembryonic lineages) but also provide a degree of developmental plasticity ensuring survival in prevailing conditions by adaptive responses. Indeed, many cellular functions including differentiation, metabolism, gene expression and gene expression regulation are subject to plasticity with short- or long-term consequences even into adult life. The interplay between intrinsic and extrinsic signals impacting on blastocyst morphogenesis is becoming clearer. This has been best studied in the mouse which will be the focus of this chapter but translational significance to human and domestic animal embryology will be a focus in future years.
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Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Velazquez, Miguel
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Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
May 2015
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Velazquez, Miguel
6e3b2e05-6341-4087-90d6-e97cd6c15d25
Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Eckert, Judith, Velazquez, Miguel and Fleming, Thomas
(2015)
Cell signalling during blastocyst morphogenesis.
In,
Leese, Henry J. and Brison, Daniel R.
(eds.)
Cell Signaling During Mammalian Early Embryo Development.
(Advances in Experimental Medicine and Biology, 843)
New York, US.
Springer, .
(doi:10.1007/978-1-4939-2480-6_1).
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Book Section
Abstract
Blastocyst morphogenesis is prepared for even before fertilisation. Information stored within parental gametes can influence both maternal and embryonic gene expression programmes after egg activation at fertilisation. A complex network of intrinsic, cell-cell mediated and extrinsic, embryo-environment signalling mechanisms operates throughout cleavage, compaction and cavitation. These signalling events not only ensure developmental progression, cell differentiation and lineage allocation to inner cell mass (embryo proper) and trophectoderm (future extraembryonic lineages) but also provide a degree of developmental plasticity ensuring survival in prevailing conditions by adaptive responses. Indeed, many cellular functions including differentiation, metabolism, gene expression and gene expression regulation are subject to plasticity with short- or long-term consequences even into adult life. The interplay between intrinsic and extrinsic signals impacting on blastocyst morphogenesis is becoming clearer. This has been best studied in the mouse which will be the focus of this chapter but translational significance to human and domestic animal embryology will be a focus in future years.
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e-pub ahead of print date: 9 May 2015
Published date: May 2015
Organisations:
Human Development & Health
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Local EPrints ID: 395348
URI: http://eprints.soton.ac.uk/id/eprint/395348
PURE UUID: 1c6ef563-9c0f-4ef8-a6f1-f0e7a9b705dd
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Date deposited: 06 Jun 2016 15:13
Last modified: 15 Mar 2024 00:39
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Author:
Miguel Velazquez
Editor:
Henry J. Leese
Editor:
Daniel R. Brison
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