The University of Southampton
University of Southampton Institutional Repository

Cell signalling during blastocyst morphogenesis

Cell signalling during blastocyst morphogenesis
Cell signalling during blastocyst morphogenesis
Blastocyst morphogenesis is prepared for even before fertilisation. Information stored within parental gametes can influence both maternal and embryonic gene expression programmes after egg activation at fertilisation. A complex network of intrinsic, cell-cell mediated and extrinsic, embryo-environment signalling mechanisms operates throughout cleavage, compaction and cavitation. These signalling events not only ensure developmental progression, cell differentiation and lineage allocation to inner cell mass (embryo proper) and trophectoderm (future extraembryonic lineages) but also provide a degree of developmental plasticity ensuring survival in prevailing conditions by adaptive responses. Indeed, many cellular functions including differentiation, metabolism, gene expression and gene expression regulation are subject to plasticity with short- or long-term consequences even into adult life. The interplay between intrinsic and extrinsic signals impacting on blastocyst morphogenesis is becoming clearer. This has been best studied in the mouse which will be the focus of this chapter but translational significance to human and domestic animal embryology will be a focus in future years.
843
1-21
Springer
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Velazquez, Miguel
6e3b2e05-6341-4087-90d6-e97cd6c15d25
Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Leese, Henry J.
Brison, Daniel R.
Eckert, Judith
729bfa49-7053-458d-8e84-3e70e4d98e57
Velazquez, Miguel
6e3b2e05-6341-4087-90d6-e97cd6c15d25
Fleming, Thomas
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Leese, Henry J.
Brison, Daniel R.

Eckert, Judith, Velazquez, Miguel and Fleming, Thomas (2015) Cell signalling during blastocyst morphogenesis. In, Leese, Henry J. and Brison, Daniel R. (eds.) Cell Signaling During Mammalian Early Embryo Development. (Advances in Experimental Medicine and Biology, 843) New York, US. Springer, pp. 1-21. (doi:10.1007/978-1-4939-2480-6_1).

Record type: Book Section

Abstract

Blastocyst morphogenesis is prepared for even before fertilisation. Information stored within parental gametes can influence both maternal and embryonic gene expression programmes after egg activation at fertilisation. A complex network of intrinsic, cell-cell mediated and extrinsic, embryo-environment signalling mechanisms operates throughout cleavage, compaction and cavitation. These signalling events not only ensure developmental progression, cell differentiation and lineage allocation to inner cell mass (embryo proper) and trophectoderm (future extraembryonic lineages) but also provide a degree of developmental plasticity ensuring survival in prevailing conditions by adaptive responses. Indeed, many cellular functions including differentiation, metabolism, gene expression and gene expression regulation are subject to plasticity with short- or long-term consequences even into adult life. The interplay between intrinsic and extrinsic signals impacting on blastocyst morphogenesis is becoming clearer. This has been best studied in the mouse which will be the focus of this chapter but translational significance to human and domestic animal embryology will be a focus in future years.

Text
__filestore.soton.ac.uk_users_jje_mydocuments_Judith_papers_Chapter 2013_finals_Springer book Eckert et al with abstract.docx - Accepted Manuscript
Restricted to Repository staff only
Request a copy

More information

e-pub ahead of print date: 9 May 2015
Published date: May 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 395348
URI: http://eprints.soton.ac.uk/id/eprint/395348
PURE UUID: 1c6ef563-9c0f-4ef8-a6f1-f0e7a9b705dd

Catalogue record

Date deposited: 06 Jun 2016 15:13
Last modified: 15 Mar 2024 00:39

Export record

Altmetrics

Contributors

Author: Judith Eckert
Author: Miguel Velazquez
Author: Thomas Fleming
Editor: Henry J. Leese
Editor: Daniel R. Brison

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×