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MicroRNAs determining inflammation as novel biomarkers and potential therapeutic targets

MicroRNAs determining inflammation as novel biomarkers and potential therapeutic targets
MicroRNAs determining inflammation as novel biomarkers and potential therapeutic targets
Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an initiating and driving component of CVDs.
0929-8673
2666-2679
Kotsinas, Athanassios
830badee-45b0-4e44-97df-65dd559aa950
Sigala, Fragkiska
93107784-c1fe-4100-ae58-4c74877cad1b
Garbis, Spiros D.
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Galyfos, Giorgos
ecd5ea56-6fe3-42b5-b55e-0b17b8fb715c
Filis, Konstantinos
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Vougas, Konstantinos
f644d6f4-269d-4d66-8f76-15d1ab17ebaa
Papalampros, Alexandros
8e6edf2e-fbf0-4805-9740-ed863e0d2855
Johnson, Elizabeth E.
029cef6f-0cf6-4bcc-b827-e77283eb3429
Chronopoulos, Efstathios
dd96cf45-6341-48ef-9460-687b07dc8f37
Georgakilas, Alexandros G.
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Gorgoulis, Vassilis G.
739295a8-eded-4d85-b1e2-e407c92a357d
Kotsinas, Athanassios
830badee-45b0-4e44-97df-65dd559aa950
Sigala, Fragkiska
93107784-c1fe-4100-ae58-4c74877cad1b
Garbis, Spiros D.
7067fd19-50c9-4d42-9611-f370289470bd
Galyfos, Giorgos
ecd5ea56-6fe3-42b5-b55e-0b17b8fb715c
Filis, Konstantinos
54532053-3f11-40c9-931d-80ada01327ac
Vougas, Konstantinos
f644d6f4-269d-4d66-8f76-15d1ab17ebaa
Papalampros, Alexandros
8e6edf2e-fbf0-4805-9740-ed863e0d2855
Johnson, Elizabeth E.
029cef6f-0cf6-4bcc-b827-e77283eb3429
Chronopoulos, Efstathios
dd96cf45-6341-48ef-9460-687b07dc8f37
Georgakilas, Alexandros G.
537671ae-515f-4cf9-a3b5-8e4f3a9d2772
Gorgoulis, Vassilis G.
739295a8-eded-4d85-b1e2-e407c92a357d

Kotsinas, Athanassios, Sigala, Fragkiska, Garbis, Spiros D., Galyfos, Giorgos, Filis, Konstantinos, Vougas, Konstantinos, Papalampros, Alexandros, Johnson, Elizabeth E., Chronopoulos, Efstathios, Georgakilas, Alexandros G. and Gorgoulis, Vassilis G. (2015) MicroRNAs determining inflammation as novel biomarkers and potential therapeutic targets. Current Medicinal Chemistry, 22 (22), 2666-2679. (doi:10.2174/0929867322666150716113304). (PMID:26180004)

Record type: Article

Abstract

Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an initiating and driving component of CVDs.

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Published date: 2015
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 395378
URI: http://eprints.soton.ac.uk/id/eprint/395378
ISSN: 0929-8673
PURE UUID: 7c0e1606-aa47-4a59-93b8-f03708bd7ff6
ORCID for Spiros D. Garbis: ORCID iD orcid.org/0000-0002-1050-0805

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Date deposited: 27 May 2016 13:25
Last modified: 15 Mar 2024 00:39

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Contributors

Author: Athanassios Kotsinas
Author: Fragkiska Sigala
Author: Spiros D. Garbis ORCID iD
Author: Giorgos Galyfos
Author: Konstantinos Filis
Author: Konstantinos Vougas
Author: Alexandros Papalampros
Author: Elizabeth E. Johnson
Author: Efstathios Chronopoulos
Author: Alexandros G. Georgakilas
Author: Vassilis G. Gorgoulis

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