Limitations of current proteomics technologies
Limitations of current proteomics technologies
Application of proteomics technologies in the investigation of biological systems creates new possibilities in the elucidation of biopathomechanisms and the discovery of novel drug targets and early disease markers. A proteomic analysis involves protein separation and protein identification as well as characterization of the post-translational modifications. Proteomics has been applied in the investigation of various disorders, like neurological diseases, and the application has resulted in the detection of a large number of differences in the levels and the modifications of proteins between healthy and diseased states. However, the current proteomics technologies are still under development and show certain limitations. In this article, we discuss the major drawbacks and pitfalls of proteomics we have observed in our laboratory and in particular during the application of proteomics technologies in the investigation of the brain.
1-18
Garbis, Spiros
7067fd19-50c9-4d42-9611-f370289470bd
Lubec, Gert
df1e61df-6184-4bd7-ae2c-3f7fb306bfcf
Fountoulakis, Michael
7918e434-8d49-49da-bd7e-45f71b6401b8
3 June 2005
Garbis, Spiros
7067fd19-50c9-4d42-9611-f370289470bd
Lubec, Gert
df1e61df-6184-4bd7-ae2c-3f7fb306bfcf
Fountoulakis, Michael
7918e434-8d49-49da-bd7e-45f71b6401b8
Abstract
Application of proteomics technologies in the investigation of biological systems creates new possibilities in the elucidation of biopathomechanisms and the discovery of novel drug targets and early disease markers. A proteomic analysis involves protein separation and protein identification as well as characterization of the post-translational modifications. Proteomics has been applied in the investigation of various disorders, like neurological diseases, and the application has resulted in the detection of a large number of differences in the levels and the modifications of proteins between healthy and diseased states. However, the current proteomics technologies are still under development and show certain limitations. In this article, we discuss the major drawbacks and pitfalls of proteomics we have observed in our laboratory and in particular during the application of proteomics technologies in the investigation of the brain.
Text
Limitations of current proteomics technologies.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: 3 June 2005
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 395429
URI: http://eprints.soton.ac.uk/id/eprint/395429
PURE UUID: 02088ede-b10d-4173-af77-1d0ed831d9d2
Catalogue record
Date deposited: 18 Jul 2016 12:41
Last modified: 15 Mar 2024 00:40
Export record
Altmetrics
Contributors
Author:
Spiros Garbis
Author:
Gert Lubec
Author:
Michael Fountoulakis
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics