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Limitations of current proteomics technologies

Limitations of current proteomics technologies
Limitations of current proteomics technologies
Application of proteomics technologies in the investigation of biological systems creates new possibilities in the elucidation of biopathomechanisms and the discovery of novel drug targets and early disease markers. A proteomic analysis involves protein separation and protein identification as well as characterization of the post-translational modifications. Proteomics has been applied in the investigation of various disorders, like neurological diseases, and the application has resulted in the detection of a large number of differences in the levels and the modifications of proteins between healthy and diseased states. However, the current proteomics technologies are still under development and show certain limitations. In this article, we discuss the major drawbacks and pitfalls of proteomics we have observed in our laboratory and in particular during the application of proteomics technologies in the investigation of the brain.
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Garbis, Spiros
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Lubec, Gert
df1e61df-6184-4bd7-ae2c-3f7fb306bfcf
Fountoulakis, Michael
7918e434-8d49-49da-bd7e-45f71b6401b8
Garbis, Spiros
7067fd19-50c9-4d42-9611-f370289470bd
Lubec, Gert
df1e61df-6184-4bd7-ae2c-3f7fb306bfcf
Fountoulakis, Michael
7918e434-8d49-49da-bd7e-45f71b6401b8

Garbis, Spiros, Lubec, Gert and Fountoulakis, Michael (2005) Limitations of current proteomics technologies. Journal of Chromatography A, 1077 (1), 1-18. (doi:10.1016/j.chroma.2005.04.059). (PMID:15988981)

Record type: Article

Abstract

Application of proteomics technologies in the investigation of biological systems creates new possibilities in the elucidation of biopathomechanisms and the discovery of novel drug targets and early disease markers. A proteomic analysis involves protein separation and protein identification as well as characterization of the post-translational modifications. Proteomics has been applied in the investigation of various disorders, like neurological diseases, and the application has resulted in the detection of a large number of differences in the levels and the modifications of proteins between healthy and diseased states. However, the current proteomics technologies are still under development and show certain limitations. In this article, we discuss the major drawbacks and pitfalls of proteomics we have observed in our laboratory and in particular during the application of proteomics technologies in the investigation of the brain.

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Published date: 3 June 2005
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 395429
URI: http://eprints.soton.ac.uk/id/eprint/395429
PURE UUID: 02088ede-b10d-4173-af77-1d0ed831d9d2
ORCID for Spiros Garbis: ORCID iD orcid.org/0000-0002-1050-0805

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Date deposited: 18 Jul 2016 12:41
Last modified: 15 Mar 2024 00:40

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Contributors

Author: Spiros Garbis ORCID iD
Author: Gert Lubec
Author: Michael Fountoulakis

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