Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells
Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells
Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanoparticles at the point of synthesis producing stable colloidal dispersions. Our results show that these biodegradable particles are not cytotoxic, and are able to penetrate and release cargo species to human brain capillary endothelial cells in vitro thus exhibiting significant potential as a novel platform for brain targeting treatments.
9053-9059
Chiacchia, M.
a8a6202b-99b0-499d-a61b-2caa4165e013
Cerutti, C.
a883e128-e231-471b-9b90-7223d4568c8f
Gromnicova, R.
e179c942-9873-49bd-b1cb-5864c99e40b9
Rietdorf, K.
56419147-2613-4f79-81cd-ee20cddf573a
Romero, I.A.
5c23f599-09ad-4140-8f32-48068ed5b078
Bradshaw, D.
7677b11e-1961-447e-b9ba-4847a74bd4dd
Chiacchia, M.
a8a6202b-99b0-499d-a61b-2caa4165e013
Cerutti, C.
a883e128-e231-471b-9b90-7223d4568c8f
Gromnicova, R.
e179c942-9873-49bd-b1cb-5864c99e40b9
Rietdorf, K.
56419147-2613-4f79-81cd-ee20cddf573a
Romero, I.A.
5c23f599-09ad-4140-8f32-48068ed5b078
Bradshaw, D.
7677b11e-1961-447e-b9ba-4847a74bd4dd
Chiacchia, M., Cerutti, C., Gromnicova, R., Rietdorf, K., Romero, I.A. and Bradshaw, D.
(2015)
Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells.
Journal of Materials Chemistry B, 3 (46), .
(doi:10.1039/C5TB01814E).
Abstract
Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanoparticles at the point of synthesis producing stable colloidal dispersions. Our results show that these biodegradable particles are not cytotoxic, and are able to penetrate and release cargo species to human brain capillary endothelial cells in vitro thus exhibiting significant potential as a novel platform for brain targeting treatments.
Text
c5tb01814e.pdf
- Version of Record
Available under License Other.
More information
e-pub ahead of print date: 26 October 2015
Organisations:
Organic Chemistry: SCF
Identifiers
Local EPrints ID: 395465
URI: http://eprints.soton.ac.uk/id/eprint/395465
ISSN: 2050-750X
PURE UUID: b71768aa-5f8f-45ad-b441-817166050439
Catalogue record
Date deposited: 31 May 2016 10:22
Last modified: 15 Mar 2024 03:40
Export record
Altmetrics
Contributors
Author:
M. Chiacchia
Author:
C. Cerutti
Author:
R. Gromnicova
Author:
K. Rietdorf
Author:
I.A. Romero
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
