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Highly diastereoselective synthesis of spiropyrazolones

Highly diastereoselective synthesis of spiropyrazolones
Highly diastereoselective synthesis of spiropyrazolones
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
8574-8582
Ceban, Victor
2e53f2b7-42ff-4c26-96e9-ef75891af166
Olomola, Temitope
b8a12c4c-8918-4c14-ba61-805de794a764
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Rios Torres, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Ceban, Victor
2e53f2b7-42ff-4c26-96e9-ef75891af166
Olomola, Temitope
b8a12c4c-8918-4c14-ba61-805de794a764
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Rios Torres, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Ceban, Victor, Olomola, Temitope, Meazza, Marta and Rios Torres, Ramon (2015) Highly diastereoselective synthesis of spiropyrazolones. Molecules, 20 (5), 8574-8582. (doi:10.3390/molecules20058574). (PMID:25985358)

Record type: Article

Abstract

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

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More information

Accepted/In Press date: 11 May 2015
Published date: 13 May 2015
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 395916
URI: https://eprints.soton.ac.uk/id/eprint/395916
PURE UUID: 3eaac727-77f3-4ac8-8cf5-bb6fa6041dcf
ORCID for Marta Meazza: ORCID iD orcid.org/0000-0003-4382-0626
ORCID for Ramon Rios Torres: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 02 Jun 2016 08:33
Last modified: 19 Jul 2019 00:42

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