The University of Southampton
University of Southampton Institutional Repository

Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load

Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load
Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load
Psychological stress-related processes are thought to contribute to the development and progression of type 2 diabetes, but the biological mechanisms involved are poorly understood. Here, we tested the notion that people with type 2 diabetes experience chronic allostatic load, manifest as dynamic disturbances in reactivity to and recovery from stress across multiple (cardiovascular, neuroendocrine, inflammatory, metabolic) biological systems, coupled with heightened experience of chronic life stress. We carried out an experimental comparison of 140 men and women aged 50-75 y with type 2 diabetes and 280 nondiabetic individuals matched on age, sex, and income. We monitored blood pressure (BP) and heart rate, salivary cortisol, plasma interleukin (IL)-6, and total cholesterol in response to standardized mental stress, and assessed salivary cortisol over the day. People with type 2 diabetes showed impaired poststress recovery in systolic and diastolic BP, heart rate and cholesterol, and blunted stress reactivity in systolic BP, cortisol, cholesterol, and IL-6. Cortisol and IL-6 concentrations were elevated, and cortisol measured over the day was higher in the type 2 diabetes group. Diabetic persons reported greater depressive and hostile symptoms and greater stress experience than did healthy controls. Type 2 diabetes is characterized by disruption of stress-related processes across multiple biological systems and increased exposure to life stress. Chronic allostatic load provides a unifying perspective with implications for etiology and patient management.
0027-8424
15693-15698
Steptoe, Andrew
aadc4799-ddd7-4013-a8c9-c37ec87f23c3
Hackett, Ruth
85636779-e303-4c6a-b22f-296e9c7fcf23
Lazzarino, Antonio
6feb9bda-0826-4c0f-b7fe-ec541bd60ee4
Bostock, Sophie
5d66bf73-84c2-4c79-bd07-f335f03e8931
La Marca, Roberto
e41dead9-ffeb-4f8e-8cd0-dbb39fbe4b50
Hamer, Mark
48304c2d-0ae4-4bd5-92ee-9833d933244c
Steptoe, Andrew
aadc4799-ddd7-4013-a8c9-c37ec87f23c3
Hackett, Ruth
85636779-e303-4c6a-b22f-296e9c7fcf23
Lazzarino, Antonio
6feb9bda-0826-4c0f-b7fe-ec541bd60ee4
Bostock, Sophie
5d66bf73-84c2-4c79-bd07-f335f03e8931
La Marca, Roberto
e41dead9-ffeb-4f8e-8cd0-dbb39fbe4b50
Hamer, Mark
48304c2d-0ae4-4bd5-92ee-9833d933244c

Steptoe, Andrew, Hackett, Ruth, Lazzarino, Antonio, Bostock, Sophie, La Marca, Roberto and Hamer, Mark (2014) Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load. Proceedings of the National Academy of Sciences, 111 (44), 15693-15698. (doi:10.1073/pnas.1410401111). (PMID:25331894)

Record type: Article

Abstract

Psychological stress-related processes are thought to contribute to the development and progression of type 2 diabetes, but the biological mechanisms involved are poorly understood. Here, we tested the notion that people with type 2 diabetes experience chronic allostatic load, manifest as dynamic disturbances in reactivity to and recovery from stress across multiple (cardiovascular, neuroendocrine, inflammatory, metabolic) biological systems, coupled with heightened experience of chronic life stress. We carried out an experimental comparison of 140 men and women aged 50-75 y with type 2 diabetes and 280 nondiabetic individuals matched on age, sex, and income. We monitored blood pressure (BP) and heart rate, salivary cortisol, plasma interleukin (IL)-6, and total cholesterol in response to standardized mental stress, and assessed salivary cortisol over the day. People with type 2 diabetes showed impaired poststress recovery in systolic and diastolic BP, heart rate and cholesterol, and blunted stress reactivity in systolic BP, cortisol, cholesterol, and IL-6. Cortisol and IL-6 concentrations were elevated, and cortisol measured over the day was higher in the type 2 diabetes group. Diabetic persons reported greater depressive and hostile symptoms and greater stress experience than did healthy controls. Type 2 diabetes is characterized by disruption of stress-related processes across multiple biological systems and increased exposure to life stress. Chronic allostatic load provides a unifying perspective with implications for etiology and patient management.

Text
15693.full.pdf - Version of Record
Download (648kB)

More information

Accepted/In Press date: 23 September 2014
Published date: October 2014
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 396018
URI: https://eprints.soton.ac.uk/id/eprint/396018
ISSN: 0027-8424
PURE UUID: 3fd84682-9241-4ef2-b66f-8349ae11f277

Catalogue record

Date deposited: 02 Jun 2016 10:56
Last modified: 30 Sep 2019 18:30

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×