DNA damage, p53, apoptosis and vascular disease

Mercer, John, Mahmoudi, Michael and Bennett, Martin (2007) DNA damage, p53, apoptosis and vascular disease. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 621 (1-2), 75-86. (doi:10.1016/j.mrfmmm.2007.02.011).

Abstract

Atherosclerosis is the commonest cause of death in the Western world. The atherosclerotic plaque shows evidence of DNA damage, activation of damage repair pathways, p53 expression and apoptosis, involving a variety of different cell types. This review summarises the evidence for DNA damage in atherosclerosis, the likely stimuli inducing damage, and the increasing role of p53 in mediating apoptosis and its consequences in atherosclerosis.

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Contributors

Author: Michael Mahmoudi

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