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DNA damage and repair in atherosclerosis

DNA damage and repair in atherosclerosis
DNA damage and repair in atherosclerosis
There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.
0008-6363
259-268
Mahmoudi, M.
1dfae087-fe15-4e03-9f1a-510a4a84a6d5
Mercer, J.
dfe4db6a-a774-4e2d-b867-61237ff2bb90
Bennett, M.
e42f5213-4410-4284-9e96-74e359df6b19
Mahmoudi, M.
1dfae087-fe15-4e03-9f1a-510a4a84a6d5
Mercer, J.
dfe4db6a-a774-4e2d-b867-61237ff2bb90
Bennett, M.
e42f5213-4410-4284-9e96-74e359df6b19

Mahmoudi, M., Mercer, J. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71 (2), 259-268. (doi:10.1016/j.cardiores.2006.03.002).

Record type: Article

Abstract

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.

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More information

Accepted/In Press date: 3 March 2006
Published date: 15 July 2006
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 396164
URI: http://eprints.soton.ac.uk/id/eprint/396164
DOI: doi:10.1016/j.cardiores.2006.03.002
ISSN: 0008-6363
PURE UUID: 592373f4-df95-47fb-b52d-599d9196fda5

Catalogue record

Date deposited: 15 Jul 2016 15:41
Last modified: 15 Mar 2024 00:47

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Contributors

Author: M. Mahmoudi
Author: J. Mercer
Author: M. Bennett

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