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The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.

The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.
The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.
Multiple sclerosis (MS) is the most common neurological disease of the central nervous system affecting young adults. While the etiology of the disease is still unknown, epidemiological and genetics studies have shown a significant inherited component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) associated with MS have been recently evaluated by two main groups of high-throughput genotyping analyses: candidate gene approaches and genome-wide association studies (GWAS). Although both types of studies have identified polymorphisms in the human leukocyte antigen (HLA) region as the strongest susceptibility loci for MS, recent investigations have identified a broad spectrum of non-HLA genes prominently associated with MS. This review will focus on recent findings in non-HLA genes as well as their SNPs which have shown high linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms will help elucidate the signalling aberrations involved in MS development and may help to identify novel, personalized approaches to therapy.
0165-5728
5-15
Bahreini, Seyed Amir
c3651700-8be5-4f7c-ba4d-9d63758f7118
Jabalameli, M. Reza
d533e702-7a6b-4f2d-8947-352ea1dd769b
Saadatnia, Mohammad
641b5041-d59c-42f2-bf23-f802114d9408
Zahednasab, Hamid
467cdf50-ec29-4ca8-8687-971764ae2654
Bahreini, Seyed Amir
c3651700-8be5-4f7c-ba4d-9d63758f7118
Jabalameli, M. Reza
d533e702-7a6b-4f2d-8947-352ea1dd769b
Saadatnia, Mohammad
641b5041-d59c-42f2-bf23-f802114d9408
Zahednasab, Hamid
467cdf50-ec29-4ca8-8687-971764ae2654

Bahreini, Seyed Amir, Jabalameli, M. Reza, Saadatnia, Mohammad and Zahednasab, Hamid (2010) The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. Journal of Neuroimmunology, 229 (1-2), 5-15. (doi:10.1016/j.jneuroim.2010.08.002). (PMID:20832869)

Record type: Article

Abstract

Multiple sclerosis (MS) is the most common neurological disease of the central nervous system affecting young adults. While the etiology of the disease is still unknown, epidemiological and genetics studies have shown a significant inherited component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) associated with MS have been recently evaluated by two main groups of high-throughput genotyping analyses: candidate gene approaches and genome-wide association studies (GWAS). Although both types of studies have identified polymorphisms in the human leukocyte antigen (HLA) region as the strongest susceptibility loci for MS, recent investigations have identified a broad spectrum of non-HLA genes prominently associated with MS. This review will focus on recent findings in non-HLA genes as well as their SNPs which have shown high linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms will help elucidate the signalling aberrations involved in MS development and may help to identify novel, personalized approaches to therapy.

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Accepted/In Press date: 4 August 2010
e-pub ahead of print date: 15 September 2010
Published date: 15 December 2010
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 396193
URI: https://eprints.soton.ac.uk/id/eprint/396193
ISSN: 0165-5728
PURE UUID: 103a3484-94da-4440-83ad-8e8a5c1945c8
ORCID for M. Reza Jabalameli: ORCID iD orcid.org/0000-0002-7762-0529

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Date deposited: 08 Jul 2016 15:55
Last modified: 06 Jun 2018 12:16

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Contributors

Author: Seyed Amir Bahreini
Author: M. Reza Jabalameli ORCID iD
Author: Mohammad Saadatnia
Author: Hamid Zahednasab

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