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Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches

Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches
Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches
Pseudomonas aeruginosa is a remarkably versatile environmental bacterium with an extraordinary capacity to infect the cystic fibrosis (CF) lung. Infection with P. aeruginosa occurs early, and although eradication can be achieved following early detection, chronic infection occurs in over 60% of adults with CF. Chronic infection is associated with accelerated disease progression and increased mortality. Extensive research has revealed complex mechanisms by which P. aeruginosa adapts to and persists within the CF airway. Yet knowledge gaps remain, and prevention and treatment strategies are limited by the lack of sensitive detection methods and by a narrow armoury of antibiotics. Further developments in this field are urgently needed in order to improve morbidity and mortality in people with CF. Here, we summarize current knowledge of pathophysiological mechanisms underlying P. aeruginosa infection in CF. Established treatments are discussed, and an overview is offered of novel detection methods and therapeutic strategies in development.
1747-6348
685-697
Lund-Palau, Helena
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Turnbull, Andrew R.
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Bush, Andrew
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Bardin, Emmanuelle
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Cameron, Lauren
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Soren, Odel
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Wierre-Gore, Natasha
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Alton, Eric W.F.W.
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Bundy, Jacob G.
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Connett, Gary
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Faust, Saul
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Filloux, Alain
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Freemont, Paul
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Jones, Andy
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Khoo, Valerie
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Morales, Sandra
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Murphy, Ronan
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Pabary, Rishi
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Simbo, Ameze
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Schelenz, Silke
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Takats, Zoltan
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Webb, Jeremey
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Williams, Hugh D.
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Davies, Jane C.
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Lund-Palau, Helena
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Turnbull, Andrew R.
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Bush, Andrew
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Bardin, Emmanuelle
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Cameron, Lauren
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Soren, Odel
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Wierre-Gore, Natasha
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Alton, Eric W.F.W.
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Bundy, Jacob G.
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Connett, Gary
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Faust, Saul
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Filloux, Alain
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Freemont, Paul
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Jones, Andy
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Khoo, Valerie
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Morales, Sandra
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Murphy, Ronan
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Pabary, Rishi
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Simbo, Ameze
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Schelenz, Silke
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Takats, Zoltan
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Webb, Jeremey
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Williams, Hugh D.
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Davies, Jane C.
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Lund-Palau, Helena, Turnbull, Andrew R., Bush, Andrew, Bardin, Emmanuelle, Cameron, Lauren, Soren, Odel, Wierre-Gore, Natasha, Alton, Eric W.F.W., Bundy, Jacob G., Connett, Gary, Faust, Saul, Filloux, Alain, Freemont, Paul, Jones, Andy, Khoo, Valerie, Morales, Sandra, Murphy, Ronan, Pabary, Rishi, Simbo, Ameze, Schelenz, Silke, Takats, Zoltan, Webb, Jeremey, Williams, Hugh D. and Davies, Jane C. (2016) Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches. Expert Review of Respiratory Medicine, 10 (6), 685-697. (doi:10.1080/17476348.2016.1177460).

Record type: Article

Abstract

Pseudomonas aeruginosa is a remarkably versatile environmental bacterium with an extraordinary capacity to infect the cystic fibrosis (CF) lung. Infection with P. aeruginosa occurs early, and although eradication can be achieved following early detection, chronic infection occurs in over 60% of adults with CF. Chronic infection is associated with accelerated disease progression and increased mortality. Extensive research has revealed complex mechanisms by which P. aeruginosa adapts to and persists within the CF airway. Yet knowledge gaps remain, and prevention and treatment strategies are limited by the lack of sensitive detection methods and by a narrow armoury of antibiotics. Further developments in this field are urgently needed in order to improve morbidity and mortality in people with CF. Here, we summarize current knowledge of pathophysiological mechanisms underlying P. aeruginosa infection in CF. Established treatments are discussed, and an overview is offered of novel detection methods and therapeutic strategies in development.

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ERRM manuscript Pa in CF revision 01 04 16 with authors.docx - Accepted Manuscript
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Accepted/In Press date: 8 April 2016
e-pub ahead of print date: 13 May 2016
Organisations: Faculty of Medicine

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Local EPrints ID: 396294
URI: http://eprints.soton.ac.uk/id/eprint/396294
ISSN: 1747-6348
PURE UUID: d42b9075-3379-468d-a71a-0d9e93f9f7a0
ORCID for Gary Connett: ORCID iD orcid.org/0000-0003-1310-3239
ORCID for Saul Faust: ORCID iD orcid.org/0000-0003-3410-7642
ORCID for Jeremey Webb: ORCID iD orcid.org/0000-0003-2068-8589

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Date deposited: 07 Jun 2016 15:12
Last modified: 18 Feb 2021 17:36

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