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Antioxidant role for lipid droplets in a stem cell niche of Drosophila

Antioxidant role for lipid droplets in a stem cell niche of Drosophila
Antioxidant role for lipid droplets in a stem cell niche of Drosophila
Stem cells reside in specialized microenvironments known as niches. During Drosophila development, glial cells provide a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation. We now find that the glial cell niche also preserves neuroblast proliferation under conditions of hypoxia and oxidative stress. Lipid droplets that form in niche glia during oxidative stress limit the levels of reactive oxygen species (ROS) and inhibit the oxidation of polyunsaturated fatty acids (PUFAs). These droplets protect glia and also neuroblasts from peroxidation chain reactions that can damage many types of macromolecules. The underlying antioxidant mechanism involves diverting PUFAs, including diet-derived linoleic acid, away from membranes to the core of lipid droplets, where they are less vulnerable to peroxidation. This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.
0092-8674
340-353
Bailey, Andrew P.
a84b3cd2-2ae1-4f4a-bc1d-93227f59276f
Koster, Grielof
e404c38a-6f48-430a-adf0-5208228cb9e7
Guillermier, Christelle
141e5a05-fd9c-4526-a045-2867bc98ea08
Hirst, Elizabeth M.A.
c98f45b7-15e4-4be2-b5c5-dc9eea73442d
MacRae, James I.
a3aeb178-dc4a-4cd9-bc05-686bb0979024
Lechene, Claude P.
3098fa8c-d7de-45a5-bd59-0874b575ebd0
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Gould, Alex P.
d898cc4f-5a14-4ef1-b7c1-5b579e99d9bd
Bailey, Andrew P.
a84b3cd2-2ae1-4f4a-bc1d-93227f59276f
Koster, Grielof
e404c38a-6f48-430a-adf0-5208228cb9e7
Guillermier, Christelle
141e5a05-fd9c-4526-a045-2867bc98ea08
Hirst, Elizabeth M.A.
c98f45b7-15e4-4be2-b5c5-dc9eea73442d
MacRae, James I.
a3aeb178-dc4a-4cd9-bc05-686bb0979024
Lechene, Claude P.
3098fa8c-d7de-45a5-bd59-0874b575ebd0
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Gould, Alex P.
d898cc4f-5a14-4ef1-b7c1-5b579e99d9bd

Bailey, Andrew P., Koster, Grielof, Guillermier, Christelle, Hirst, Elizabeth M.A., MacRae, James I., Lechene, Claude P., Postle, Anthony D. and Gould, Alex P. (2015) Antioxidant role for lipid droplets in a stem cell niche of Drosophila. Cell, 163 (2), 340-353. (doi:10.1016/j.cell.2015.09.020). (PMID:26451484)

Record type: Article

Abstract

Stem cells reside in specialized microenvironments known as niches. During Drosophila development, glial cells provide a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation. We now find that the glial cell niche also preserves neuroblast proliferation under conditions of hypoxia and oxidative stress. Lipid droplets that form in niche glia during oxidative stress limit the levels of reactive oxygen species (ROS) and inhibit the oxidation of polyunsaturated fatty acids (PUFAs). These droplets protect glia and also neuroblasts from peroxidation chain reactions that can damage many types of macromolecules. The underlying antioxidant mechanism involves diverting PUFAs, including diet-derived linoleic acid, away from membranes to the core of lipid droplets, where they are less vulnerable to peroxidation. This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.

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Accepted/In Press date: 12 August 2015
Published date: 8 October 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 396297
URI: https://eprints.soton.ac.uk/id/eprint/396297
ISSN: 0092-8674
PURE UUID: 8db2f852-6b6c-4c5d-996b-e2a0c4691fc4
ORCID for Anthony D. Postle: ORCID iD orcid.org/0000-0001-7361-0756

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Date deposited: 07 Jun 2016 15:18
Last modified: 09 Feb 2019 01:39

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Contributors

Author: Andrew P. Bailey
Author: Grielof Koster
Author: Christelle Guillermier
Author: Elizabeth M.A. Hirst
Author: James I. MacRae
Author: Claude P. Lechene
Author: Alex P. Gould

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