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Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming

Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming
Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming
Addition of bioactive materials such as calcium phosphates or Bioglass, and incorporation of porosity into polyetheretherketone (PEEK) has been identified as an effective approach to improve bone-implant interfaces and osseointegration of PEEK-based devices. In this paper, a novel production technique based on the extrusion freeforming method is proposed that yields a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the bioactive phase (i.e., HA) distribution is computer-controlled within a PEEK matrix. The 100% interconnectivity of the HA network in the biocomposite confers an advantage over alternative forms of other microstructural configurations. Moreover, the technique can be employed to produce porous PEEK structures with controlled pore size and distribution, facilitating greater cellular infiltration and biological integration of PEEK composites within patient tissue. The results of unconfined, uniaxial compressive tests on these new PEEK/HA biocomposites with 40% HA under both static and cyclic mode were promising, showing the composites possess yield and compressive strength within the range of human cortical bone suitable for load bearing applications. In addition, preliminary evidence supporting initial biological safety of the new technique developed is demonstrated in this paper. Sufficient cell attachment, sustained viability in contact with the sample over a seven-day period, evidence of cell bridging and matrix deposition all confirmed excellent biocompatibility.
1-21
Vaezi, Mohammad
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Black, Cameron
7f616e37-4d80-4f60-ac8d-ba96e583db72
Gibbs, David M.R.
4e8e4ea5-eaf5-4f93-8baf-88b524885893
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Brady, Mark
09935fdf-eb02-482b-b510-339cd4a3aa3e
Moshrefi-Torbati, Mohamed
65b351dc-7c2e-4a9a-83a4-df797973913b
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1
Vaezi, Mohammad
828e14c1-3236-4153-8f69-3837233f48ed
Black, Cameron
7f616e37-4d80-4f60-ac8d-ba96e583db72
Gibbs, David M.R.
4e8e4ea5-eaf5-4f93-8baf-88b524885893
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Brady, Mark
09935fdf-eb02-482b-b510-339cd4a3aa3e
Moshrefi-Torbati, Mohamed
65b351dc-7c2e-4a9a-83a4-df797973913b
Yang, Shoufeng
e0018adf-8123-4a54-b8dd-306c10ca48f1

Vaezi, Mohammad, Black, Cameron, Gibbs, David M.R., Oreffo, Richard O.C., Brady, Mark, Moshrefi-Torbati, Mohamed and Yang, Shoufeng (2016) Characterization of new PEEK/HA composites with 3D HA network fabricated by extrusion freeforming. Molecules, 21 (6), 1-21. (doi:10.3390/molecules21060687). (PMID:27240326)

Record type: Article

Abstract

Addition of bioactive materials such as calcium phosphates or Bioglass, and incorporation of porosity into polyetheretherketone (PEEK) has been identified as an effective approach to improve bone-implant interfaces and osseointegration of PEEK-based devices. In this paper, a novel production technique based on the extrusion freeforming method is proposed that yields a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the bioactive phase (i.e., HA) distribution is computer-controlled within a PEEK matrix. The 100% interconnectivity of the HA network in the biocomposite confers an advantage over alternative forms of other microstructural configurations. Moreover, the technique can be employed to produce porous PEEK structures with controlled pore size and distribution, facilitating greater cellular infiltration and biological integration of PEEK composites within patient tissue. The results of unconfined, uniaxial compressive tests on these new PEEK/HA biocomposites with 40% HA under both static and cyclic mode were promising, showing the composites possess yield and compressive strength within the range of human cortical bone suitable for load bearing applications. In addition, preliminary evidence supporting initial biological safety of the new technique developed is demonstrated in this paper. Sufficient cell attachment, sustained viability in contact with the sample over a seven-day period, evidence of cell bridging and matrix deposition all confirmed excellent biocompatibility.

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Accepted/In Press date: 20 May 2016
e-pub ahead of print date: 26 May 2016
Published date: 26 May 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 396362
URI: http://eprints.soton.ac.uk/id/eprint/396362
PURE UUID: 0a8af8fd-d9ac-42b3-9058-5c60778aa688
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for Shoufeng Yang: ORCID iD orcid.org/0000-0002-3888-3211

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Date deposited: 08 Jun 2016 14:53
Last modified: 17 Mar 2021 02:42

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Contributors

Author: Mohammad Vaezi
Author: Cameron Black
Author: David M.R. Gibbs
Author: Mark Brady
Author: Shoufeng Yang ORCID iD

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