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Developmental origins of epigenetic transgenerational inheritance

Developmental origins of epigenetic transgenerational inheritance
Developmental origins of epigenetic transgenerational inheritance
Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance and has been shown in a variety of species including plants, flies, worms, fish, rodents, pigs, and humans. This phenomenon operates during specific critical windows of exposure, linked to the developmental biology of the germ cells (sperm and eggs). Therefore, concepts of the developmental origins of transgenerational inheritance of phenotypic variation and subsequent disease risk need to include epigenetic processes affecting the developmental biology of the germ cell. These developmental impacts on epigenetic transgenerational inheritance, in contrast to multigenerational exposures, are the focus of this Perspective.
1-9
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Skinner, Michael K.
e13f36b2-d488-4b83-bf7b-86545f300b62
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Skinner, Michael K.
e13f36b2-d488-4b83-bf7b-86545f300b62

Hanson, Mark A. and Skinner, Michael K. (2016) Developmental origins of epigenetic transgenerational inheritance. Environmental Epigenetics, 2 (1), 1-9. (doi:10.1093/eep/dvw002).

Record type: Article

Abstract

Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance and has been shown in a variety of species including plants, flies, worms, fish, rodents, pigs, and humans. This phenomenon operates during specific critical windows of exposure, linked to the developmental biology of the germ cells (sperm and eggs). Therefore, concepts of the developmental origins of transgenerational inheritance of phenotypic variation and subsequent disease risk need to include epigenetic processes affecting the developmental biology of the germ cell. These developmental impacts on epigenetic transgenerational inheritance, in contrast to multigenerational exposures, are the focus of this Perspective.

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More information

Accepted/In Press date: 31 January 2016
Published date: March 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 396523
URI: http://eprints.soton.ac.uk/id/eprint/396523
PURE UUID: bbd2f42e-ba4c-4949-bb4c-b50f78e7911d
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 10 Jun 2016 10:53
Last modified: 18 Jul 2020 00:27

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Contributors

Author: Mark A. Hanson ORCID iD
Author: Michael K. Skinner

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